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SCP0082

Sigma-Aldrich

Caspase 3 Apopain Substrate

≥95% (HPLC), lyophilized

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5 G
CHF 243.00

CHF 243.00

Estimated to ship on2025年5月12日

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5 G
CHF 243.00

About This Item

Empirical Formula (Hill Notation):
C36H38N5O14
Molecular Weight:
764.71
UNSPSC Code:
12352202
NACRES:
NA.32

CHF 243.00

Estimated to ship on2025年5月12日

Product Name

Caspase 3 Apopain Substrate,

Assay

≥95% (HPLC)

form

lyophilized

composition

Peptide Content, ≥80%

storage condition

protect from light

storage temp.

−20°C

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sterility

sterile-filtered

sterility

sterile-filtered

sterility

sterile-filtered

sterility

-

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

components

NaHCO3: no
phenol red: yes
sodium pyruvate: no
HEPES: no
Earle’s salts (5% CO2): yes
L-glutamine: no

components

phenol red: yes
HEPES: no
sodium pyruvate: no
Hanks’ salts (2% CO2): yes
L-glutamine: no
NaHCO3: no

components

L-glutamine: no
sodium pyruvate: no
HEPES: 25 mM
phenol red: yes
NaHCO3: yes
Earle’s salts (5% CO2): yes

components

L-glutamine: yes
phenol red: yes
NaHCO3: no
sodium pyruvate: no
Earle’s salts (5% CO2): yes
HEPES: no

shipped in

ambient

shipped in

ambient

shipped in

ambient

shipped in

ambient

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

Amino Acid Sequence

Z-Asp-Glu-Val-Asp-AFC

Application

Caspase 3, a cysteine protease activator of caspase 6 and caspase 7, metabolizes amyloid-β 4A precursor protein. Caspase 3 may be detected using a variety of chromogenic and fluorogenic peptide substrates built around the DxxD (asp-x-x-asp) sequences DMQD and DEVD such as Ac-DMQD-pNa (Acetyl-Asp-Met-Gln-Asp-p- nitroanalide), chromogenic; Ac-DMQD-AMC (Acetyl-Asp-Met-Gln-Asp-amino-4-methylcoumarin), fluorogenic; Z-DEVD-AFC (Z-Asp-Glu-Val-Asp-AFC), flourogenic and Ac-DEVD-4M2Na.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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    Certificates of Analysis (COA)

    Lot/Batch Number
    LM0818

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    The Journal of investigative dermatology, 112(5), 769-774 (1999-05-08)
    Exposure of human keratinocyte HaCaT cells to ultraviolet B-irradiation induced apoptotic morphologic changes. In this study, we found that the ultraviolet B irradiation (0.25 J per cm2) induced phosphorylation of p38 mitogen-activated protein kinase and c-jun N-terminal protein kinase, and
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    The response of human myeloid leukemia cells to treatment with 1-beta-arabinofuranosylcytosine (ara-C) includes the induction of apoptosis. Ara-C induced apoptosis is associated with proteolytic cleavage of poly(ADP-ribose) polymerase (PARP) and protein kinase C (PKC) delta. However, the signals involved in
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    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 15(6), 672-678 (2008-04-02)
    We investigated the therapeutic efficacy of Ac-DMQD-CHO, a caspase-3 inhibitor, and functional recovery in spinal cord injury in a rat model. Thirty rats were randomized into three groups of 10 each. In groups 2 and 3, spinal cord trauma was

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