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Key Documents

SAB4504044

Sigma-Aldrich

Anti-phospho-Myosin regulatory light chain 2 (pSer18) antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-CMH10, Anti-MFM12, Anti-MLC-2s/v, Anti-MLC2

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 19 kDa

species reactivity

human, rat, mouse

concentration

~1 mg/mL

technique(s)

ELISA: 1:20000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

NCBI accession no.

P24844

UniProt accession no.

P10916

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

phosphorylation (pSer18)

Gene Information

human ... MYL2(4633)

General description

MYL2 (myosin light chain 2) encodes a myosin regulatory light chain (MLC-2V). It is made of two heavy chains, two essential light chains and two regulatory light chains. It is located on human chromosome 12q24.

Immunogen

The antiserum was produced against synthesized peptide derived from human Myosin regulatory light chain 2 around the phosphorylation site of Ser18.

Immunogen Range: 3-52

Biochem/physiol Actions

MYL2 (myosin light chain 2) helps to convert energy from ATP hydrolysis into mechanical force. This gene also plays a major role in the growth and progression of chronic HF (heart failure). Mutation in MYL2 gene result in infantile type I muscle fibre disease and cardiomyopathy.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Slow cardiac myosin regulatory light chain 2 (MYL2) was down-expressed in chronic heart failure patients
Li Y, et al.
Clinical Cardiology, 34(1), 30-34 (2011)
Detailed mapping, mutation analysis, and intragenic polymorphism identification in candidate Noonan syndrome genes MYL2,DCN, EPS8, andRPL6
ION A, et al.
Journal of medical Genetics, 37(11), 884-886 (2000)
Recessive MYL2 mutations cause infantile type I muscle fibre disease and cardiomyopathy
Weterman MA, et al.
Brain (2013)

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