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Key Documents

S8758

Sigma-Aldrich

N-Succinyl-Ala-Ala-Phe-7-amido-4-methylcoumarin

protease substrate, ≥98%, powder

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About This Item

Empirical Formula (Hill Notation):
C29H32N4O8
CAS Number:
Molecular Weight:
564.59
MDL number:
UNSPSC Code:
12352204
PubChem Substance ID:
NACRES:
NA.32

product name

N-Succinyl-Ala-Ala-Phe-7-amido-4-methylcoumarin, protease substrate

Quality Level

Assay

≥98%

form

powder

solubility

50% acetic acid: 1 mg/mL, clear, colorless

storage temp.

−20°C

SMILES string

CC(NC(=O)CCC(O)=O)C(=O)NC(C)C(=O)NC(Cc1ccccc1)C(=O)Nc2ccc3C(C)=CC(=O)Oc3c2

InChI

1S/C29H32N4O8/c1-16-13-26(37)41-23-15-20(9-10-21(16)23)32-29(40)22(14-19-7-5-4-6-8-19)33-28(39)18(3)31-27(38)17(2)30-24(34)11-12-25(35)36/h4-10,13,15,17-18,22H,11-12,14H2,1-3H3,(H,30,34)(H,31,38)(H,32,40)(H,33,39)(H,35,36)

InChI key

HHPVJKZZYOXPLH-UHFFFAOYSA-N

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Naoto Watamura et al.
Molecular psychiatry (2021-11-06)
Alzheimer's disease (AD) is characterized by the deposition of amyloid β peptide (Aβ) in the brain. The neuropeptide somatostatin (SST) regulates Aβ catabolism by enhancing neprilysin (NEP)-catalyzed proteolytic degradation. However, the mechanism by which SST regulates NEP activity remains unclear.

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