PLA0054

Goat anti-Chk1 Antibody, Affinity Purified

• Synonym(s): 1, CHK1, CHK1 (checkpoint; S.pombe) homolog, CHK1 checkpoint homolog, CHK1 checkpoint homolog (S. pombe), Checkpoint, Chk1-S, S. pombe, cell cycle checkpoint kinase, checkpoint kinase-1, homolog of
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: goat
• Quality Level: 100
• antibody form: affinity purified immunoglobulin
• antibody product type: primary antibodies
• species reactivity: human
• technique(s): western blot: 1:2,500- 1:15,000
• accession no.: NP_001265.1
• shipped in: wet ice
• storage temp.: 2-8°C
• Gene Information: goat ... Chk1(1111)

Description

Immunogen

The epitope recognized by PLA0054 maps to a region between residues 200 and 250 of human Checkpoint Kinase 1 using the numbering given in entry NP_001265.1 (GeneID 1111).

Physical form

Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% sodium azide

Other Notes

Chk1 functions as a checkpoint protein kinase that is critical to the regulation of the Cdc25a and Cdc25c phosphatases that promote S and G2/M phase progression, respectively. Chk1 kinase activity inhibits cell cycle progression in the presence of DNA damage by phosphorylating Cdc25a and Cdc25c and causing the degradation of Cdc25a and cytoplasmic sequestration of Cdc25c.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: nwg
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable