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P9547

Sigma-Aldrich

Prilocaine hydrochloride

≥98% (TLC)

Synonym(s):

N-(2-Methylphenyl)-2-(propylamino)propanamide hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C13H20N2O · HCl
CAS Number:
1786-81-8
Molecular Weight:
256.77
EC Number:
217-244-0
MDL number:
MFCD00079279
UNSPSC Code:
12352200
PubChem Substance ID:
57654573
NACRES:
NA.77

Assay

≥98% (TLC)

form

powder

originator

AstraZeneca

SMILES string

Cl[H].CCCNC(C)C(=O)Nc1ccccc1C

InChI

1S/C13H20N2O.ClH/c1-4-9-14-11(3)13(16)15-12-8-6-5-7-10(12)2;/h5-8,11,14H,4,9H2,1-3H3,(H,15,16);1H

InChI key

BJPJNTKRKALCPP-UHFFFAOYSA-N

Gene Information

human ... SCN10A(6336) , SCN11A(11280) , SCN1A(6323) , SCN2A(6326) , SCN3A(6328) , SCN4A(6329) , SCN5A(6331) , SCN7A(6332) , SCN8A(6334) , SCN9A(6335)

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Biochem/physiol Actions

Used for local nerve block and for spinal anesthesia; pharmacological properties are similar to those of lidocaine.

Features and Benefits

This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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K Nakamura et al.
Canadian journal of anaesthesia = Journal canadien d'anesthesie, 46(5 Pt 1), 476-482 (1999-06-01)
To determine whether prilocaine, a local anesthetic, induces apoptosis in osteoblastic cells. After reaching subconfluence, human osteoblastic Saos-2 and MG63 cells and mouse osteoblastic MC3T3-E1 cells were exposed for 48 hr to varying concentrations of prilocaine up to 10 mM
Austin Larson et al.
Pediatric emergency care, 29(3), 377-379 (2013-03-07)
Topical anesthetics are commonly used in many health care settings and for many clinical conditions. However, there are a number of potential adverse effects associated with their use. Their widespread administration can convey a false sense of security and failure
Stephanie C J Keating et al.
PloS one, 7(9), e44437-e44437 (2012-09-13)
Ear tattooing is a routine procedure performed on laboratory, commercial and companion rabbits for the purpose of identification. Although this procedure is potentially painful, it is usually performed without the provision of analgesia, so compromising animal welfare. Furthermore, current means
Nezih Sertoz et al.
Foot & ankle international, 34(1), 85-90 (2013-02-07)
The objective of the present study was to explore the effects of deficiencies in glucose regulation on the onset, regression, and block performance times in a group of patients with diabetes-related foot problems. Forty-eight patients with American Society of Anesthetists
P K Gupta et al.
British journal of anaesthesia, 110(5), 831-836 (2013-02-09)
Our aim was to estimate the ED95 of prilocaine 1% w/v for femoral nerve block. This two-stage dose-finding sequential clinical trial followed an adaptive design based on the continual reassessment method (CRM). Adult patients undergoing Vastus medialis muscle biopsy under
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