P3292

Pancreatin from porcine pancreas

powder, suitable for cell culture, 4 × USP specifications

• Synonym(s): Pancreatin from hog pancreas
• CAS Number: 8049-47-6
• EC Number: 232-468-9
• MDL number: MFCD00131789
• UNSPSC Code: 12352204
• NACRES: NA.75

Properties

• biological source: Porcine pancreas
• Agency: USP (specifications)
• form: powder
• specific activity: 4 × USP specifications
• contains: lactose or sucrose as extender (The sucrose used might contain up to 3.25% starch.)
• technique(s): cell culture | mammalian: suitable
• shipped in: ambient
• storage temp.: −20°C

Description

Application

Pancreatin from porcine pancreas has been used to assess the treatment of steatorrhea by lipase supplementation therapy, to investigate treatment options for pancreatic diabetes in patients experiencing the decompensated stage of chronic pancreatitis, and to safely and effectively remove formalin-fixed tissues from arterial grafts without leading to structural damage or loss in fiber integrity.

Biochem/physiol Actions

Pancreatin contains enzymatic components including trypsin, amylase and lipase, ribonuclease, and protease, produced by the exocrine cells of the porcine pancreas. This combination of enzymes allows it to hydrolyze proteins, starch and fats. Pancreatin will convert not less than 25 times its weight of potato starch into soluble carbohydrates in 5 minutes in water at 40°C, will digest not less than 25 times its weight of casein in 60 minutes at pH 7.5 at 40°C and will release not less than microequivalents of acid per min per mg pancreatin from olive oil at pH 9.0 at 37°C.

Safety Information

• Pictograms: GHS08,GHS07
• Signal Word: Danger
• Hazard Statements: H315,H317,H319,H334,H335
• Precautionary Statements: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1