M5273

Monensin sodium salt

90-95% (TLC)

• Synonym(s): Monensin A sodium salt
• Empirical Formula (Hill Notation): C₃₆H₆₁NaO₁₁
• CAS Number: 22373-78-0
• Molecular Weight: 692.85
• Beilstein: 4122200
• EC Number: 244-941-7
• MDL number: MFCD00077826
• UNSPSC Code: 12352200
• PubChem Substance ID: 24896992
• NACRES: NA.77

Properties

• Assay: 90-95% (TLC)
• antibiotic activity spectrum: Gram-negative bacteria; Gram-positive bacteria; fungi; parasites; viruses
• Mode of action: cell membrane | interferes
• storage temp.: 2-8°C
• SMILES string: [H][C@]1([C@@]2(CC)O[C@]([C@@]3(C)OC4(C[C@H](O)[C@@H](C)[C@@]([H])([C@@H](C)[C@@H](OC)[C@@H](C([O-])=O)C)O4)CC3)([H])CC2)[C@@H](C)C[C@]([H])([C@@]5([H])O[C@@](O)(CO)[C@H](C)C[C@@H]5C)O1.[Na+]
• InChI: 1S/C36H62O11.Na/c1-10-34(31-20(3)16-26(43-31)28-19(2)15-21(4)36(41,18-37)46-28)12-11-27(44-34)33(8)13-14-35(47-33)17-25(38)22(5)30(45-35)23(6)29(42-9)24(7)32(39)40;/h19-31,37-38,41H,10-18H2,1-9H3,(H,39,40);/q;+1/p-1/t19-,20-,21+,22+,23-,24-,25-,26+,27+,28-,29+,30-,31+,33-,34-,35?,36-;/m0./s1
• InChI key: XOIQMTLWECTKJL-BEMBKCOJSA-M

Description

General description

Chemical structure: polyether

Monensin is a polyether ionophoric antibiotic, which is produced by Streptomyces cinnamonensis. It is used to treat bacterial, fungal and parasitic infections. Monensin prevents the growth of colon cancer cells. It facilitates the transport of sodium and potassium ions between intracellular and extracellular spaces. Monensin prevents coccidiosis in poultry production.

Application

Monensin sodium salt has been used:

• for the intracellular staining of cytokines
• to study its effects on the regulation of nuclear factor-κ B (NF-κB ) activation
• as a positive control to study its effects on in vitro rumen fermentation

Biochem/physiol Actions

Na⁺ ionophore; blocks glycoprotein secretion; may induce catecholamine secretion from chromaffin cells. Useful in potentiometric and spectroscopic studies of alkali metal ion complexes.

Preparation Note

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.

Safety Information

• Pictograms: GHS06,GHS08,GHS09
• Signal Word: Danger
• Hazard Statements: H300,H319,H373,H411
• Precautionary Statements: P260 - P264 - P273 - P301 + P310 - P305 + P351 + P338 - P314
• Hazard Classifications: Acute Tox. 2 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - STOT RE 2
• Target Organs: Heart,muscle
• Storage Class Code: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves