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D1694

Sigma-Aldrich

Anti-DYRK1A (N-terminal) antibody produced in rabbit

~1.5 mg/mL, affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-Dual-specificity tyrosine-phosphorylation-regulated kinase 1A, Anti-MBN/MNBH, Anti-MNB protein kinase, Anti-Minibrain Drosophila homolog

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~86 kDa

species reactivity

rat, mouse, human

concentration

~1.5 mg/mL

technique(s)

western blot: 1.5-3 μg/mL using rat brain embryonic extract (S1 fraction)
western blot: 3-5 μg/mL using PC12 cell lyste

UniProt accession no.

Q13627

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... DYRK1A(1859)
mouse ... Dyrk1a(13548)
rat ... Dyrk1a(25255)

General description

DYRK1A (dual-specificity tyrosine-phosphorylated regulated kinase 1A) is a member of a growing family of Ser/Thr protein kinases termed DYRKs.
The human and rodent DYRK1A are ubiquitously expressed in adult and fetal tissue with high expression in the brain and heart during development.

Application

Anti-DYRK1A (N-terminal) antibody produced in rabbit has been used in immunoblotting and immunohistochemistry.

Biochem/physiol Actions

DYRK1A is encoded by a gene located within the Down syndrome (DS) critical region on human chromosome 21 and its expression is found to be elevated in individuals with DS. It might be one of the genes involved in some of the neurological abnormalities observed in DS. It phosphorylates several substrates including transcription factor FKHR, NFAT, STAT3, microtubule-associated protein Tau, glycogen synthase and c-AMP-response element-binding protein.

Target description

DYRK1A (N-terminal) encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-c

Physical form

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Mark Meyers et al.
The Journal of biological chemistry, 280(7), 5516-5526 (2004-12-22)
Previous studies from our laboratory indicated that expression of the MLH1 DNA mismatch repair (MMR) gene was necessary to restore cytotoxicity and an efficient G(2) arrest in HCT116 human colon cancer cells, as well as Mlh1(-/-) murine embryonic fibroblasts, after
Dyrk1A haploinsufficiency affects viability and causes developmental delay and abnormal brain morphology in mice
Fotaki V, et al.
Molecular and cellular biology, 22(18), 6636-6647 (2002)
Manon Moreau et al.
Biomedicines, 10(6) (2022-06-25)
Down syndrome (DS) is a complex genetic condition due to an additional copy of human chromosome 21, which results in the deregulation of many genes. In addition to the intellectual disability associated with DS, adults with DS also have an
Protein profile and morphological alterations in penumbra after focal photothrombotic infarction in the rat cerebral cortex
Uzdensky A, et al.
Molecular Neurobiology, 54(6), 4172-4188 (2017)
Benoît Souchet et al.
Acta neuropathologica communications, 7(1), 46-46 (2019-03-20)
Recent evidences suggest the involvement of DYRK1A (dual specificity tyrosine phosphorylation-regulated kinase 1 A) in Alzheimer's disease (AD). Here we showed that DYRK1A undergoes a proteolytic processing in AD patients hippocampus without consequences on its kinase activity. Resulting truncated forms
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