A9062

Adenosine 5′-triphosphate di(tris) salt hydrate

≥95%

• Synonym(s): ATP, 5′-ATP-DiTris
• Empirical Formula (Hill Notation): C₁₀H₁₆N₅O₁₃P₃ · 2C₄H₁₁NO₃ · xH₂O
• CAS Number: 102047-34-7
• Molecular Weight: 749.45 (anhydrous basis)
• UNSPSC Code: 41106305
• eCl@ss: 32160414
• PubChem Substance ID: 24891222
• NACRES: NA.51

Properties

• biological source: (Fermentation)
• Quality Level: 200
• Assay: ≥95%
• form: powder
• solubility: H₂O: 50 mg/mL
• cation traces: Na: ≤0.1%
• shipped in: dry ice
• storage temp.: −20°C
• SMILES string: O.NC(CO)(CO)CO.NC(CO)(CO)CO.Nc1ncnc2n(cnc12)[C@@H]3O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]3O
• InChI: 1S/C10H16N5O13P3.2C4H11NO3.H2O/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20;2*5-4(1-6,2-7)3-8;/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20);2*6-8H,1-3,5H2;1H2/t4-,6-,7-,10-;;;/m1.../s1
• InChI key: ZMNHJZFDZFGOFE-MSQVLRTGSA-N

Description

Application

Adenosine 5′-triphosphate di(tris) salt hydrate has been used:

• to treat cells for Ca²⁺ influx measurements in stromal interaction molecule 1 knockout (STIM1−/−) mice and in vitro chemotaxis assay for microglial migration
• supplemented in buffer C for mitochondrial respiratory control assay and complex V activity assay
• in the inhibition of silver nano particles (AgNPs) on Na⁺/K⁺-ATPase activity

Biochem/physiol Actions

Adenosine 5′-triphosphate di(tris) salt dehydrate is useful in applications that require the absence of metals.
Adenosine 5′-triphosphate (ATP) is a central component of energy storage and metabolism in vivo. ATP is use in many cellular processes, respiration, biosynthetic reactions, motility, and cell division. ATP is a substrate of many kinases involved in cell signaling and of adenylate cyclase(s) that produce the second messenger cAMP. ATP provides the metabolic energy to drive metabolic pumps. ATP serves as a coenzyme in a wide array of enzymatic reactions.

P₂ purinergic agonist; increases activity of Ca²⁺-activated K⁺ channels; substrate for ATP-dependent enzyme systems

Caution

Unstable: For maximum stability, store as frozen solution at pH 3.5 to 6.8.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H315 - H319 - H335
• Precautionary Statements: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves