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Validamycin A

PESTANAL®, analytical standard

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About This Item

Empirical Formula (Hill Notation):
C20H35NO13
CAS Number:
Molecular Weight:
497.49
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24

grade

analytical standard

Quality Level

product line

PESTANAL®

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

agriculture
environmental
forensics and toxicology
veterinary

format

neat

storage temp.

2-8°C

SMILES string

O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@@H](CO)C[C@H](N[C@H]3C=C(CO)[C@@H](O)[C@H](O)[C@H]3O)[C@H](O)[C@H]2O)O[C@H](CO)[C@H]1O

InChI

1S/C20H35NO13/c22-3-6-1-8(12(26)15(29)11(6)25)21-9-2-7(4-23)19(17(31)13(9)27)34-20-18(32)16(30)14(28)10(5-24)33-20/h1,7-32H,2-5H2/t7-,8+,9+,10-,11-,12+,13+,14-,15+,16+,17-,18-,19-,20+/m1/s1

InChI key

JARYYMUOCXVXNK-CSLFJTBJSA-N

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General description

Validamycin A is an antifungal aminoglycoside antibiotic produced by Streptomyces hygroscopicus. It is widely used as a plant protection reagent for the treatment of rice sheath blight disease in plants.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Validamycin A may be used as a reference standard in the determination of validamycin A in commercial products and food products using micellar electrokinetic capillary chromatographic technique (MEKC)and liquid chromatography coupled with atmospheric pressure chemical ionization–tandem mass spectrometry (LC–APCI–MS/MS).

Legal Information

PESTANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Determination of validamycin A in agricultural food samples by solid-phase extraction combined with liquid chromatography?atmospheric pressure chemical ionisation?tandem mass spectrometry.
Wang C, et al.
Food Chemistry, 169, 150-155 (2015)
Determination of the antibiotic fungicide validamycin A in formulated products by micellar electrokinetic chromatography.
Hsiao M-Y and Lo C-C
Journal of Agricultural and Food Chemistry, 47(9), 3723-3726 (1999)
Jae Jin Lee et al.
Nature communications, 10(1), 2928-2928 (2019-07-04)
Stochastic formation of Mycobacterium tuberculosis (Mtb) persisters achieves a high level of antibiotic-tolerance and serves as a source of multidrug-resistant (MDR) mutations. As conventional treatment is not effective against infections by persisters and MDR-Mtb, novel therapeutics are needed. Several approaches
Brian P O'Neill et al.
SpringerPlus, 1(1), 74-74 (2013-03-30)
To engineer trehalose metabolism in sugarcane (Saccharum spp. hybrids) two transgenes were introduced to the genome: trehalose-6-phosphate synthase- phosphatase (TPSP), to increase trehalose biosynthesis and an RNAi transgene specific for trehalase, to abrogate trehalose catabolism. In RNAi-expressing lines trehalase expression
Effect of fermentation temperature on validamycin A production by Streptomyces hygroscopicus 5008.
Liao Y, et al.
Journal of Biotechnology, 142(3-4), 271-274 (2009)

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