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Key Documents

ABC42-M

Sigma-Aldrich

Anti-Mitofusin-2 (Mfn2) Antibody

from rabbit, purified by affinity chromatography

Synonym(s):

Mitofusin-2, Transmembrane GTPase MFN2

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

rat, human

species reactivity (predicted by homology)

mouse (based on 100% sequence homology)

technique(s)

western blot: suitable

NCBI accession no.

NP_055689

UniProt accession no.

O95140

target post-translational modification

unmodified

Gene Information

human ... MFN2(9927)

General description

Mitofusin-2 (Mfn2) is a membrane protein of the mitochondria and is important in mitochondrial fusion in mammalian cells. Mfn2 activity has also been implicated in mitochondrial metabolism and the loss of Mfn2 may be the reason for certain metabolic modifications that are seen in individuals with obesity. Mfn2 has been associated with maintaining the membrane potential of the mitochondria. Mfn2 has been shown to hinder mitochondrial antiviral signaling by inhibiting production of type 1 interferons. Mfn2 is a p53-inducible target and involved in cell proliferation, apoptosis promotion and tumor suppression.

Specificity

This antibody recognizes Mitofusin-2 (Mfn2) at the coiled coil region of the cytoplasmic domain.

Immunogen

Epitope: Coiled Coil Region of the Cytoplasmic Domain
KLH-conjugated linear peptide corresponding to the cytoplasmic domain of human Mitofusin-2 (Mfn2).

Application

Detect Mitofusin-2 (Mfn2) using this Anti-Mitofusin-2 (Mfn2) Antibody validated for use in WB.

Quality

Evaluated by Western Blot in human heart tissue lysate.

Western Blot Analysis: 0.5 µg/mL of this antibody detected Mitofusion-2 (Mfn2) in 10 µg of human heart tissue lysate.

Target description

~86 kDa observed.
Mitofusion-2 (Mfn2) exists as 2 isoforms produced by alternative splicing with molecular weights of ~86 kDa and ~50 kDa

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Daniel Chauss et al.
G3 (Bethesda, Md.), 4(8), 1515-1527 (2014-06-15)
The mature eye lens contains a surface layer of epithelial cells called the lens epithelium that requires a functional mitochondrial population to maintain the homeostasis and transparency of the entire lens. The lens epithelium overlies a core of terminally differentiated

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