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Key Documents

AB1735

Sigma-Aldrich

Anti-Bid Antibody

serum, Chemicon®

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

serum

antibody product type

primary antibodies

clone

polyclonal

species reactivity

mouse, human, rat, rabbit

manufacturer/tradename

Chemicon®

technique(s)

immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

NCBI accession no.

NM_001196.2
NM_197966.1
NM_197967.1

UniProt accession no.

P55957

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

human ... BID(637)

General description

Bid, a BH3 domain-containing proapoptotic Bcl-2 family member, is known to interact with Bcl-2 and Bax. It has been reported that Bid induces cytochrome c release from mitochondria following cleavage by caspase-8 in response to apoptotic stimuli transmitted through cell surface death receptors. The cytochrome c releasing activity of Bid was antagonized by Bcl-2. Mutation in the SH3 domain can diminish the cytochrome c releasing activity. In animal model studies, Bid-deficient mice are found resistant to the lethal effects of death factor signals relayed through Fas.

Specificity

AB1735 recognizes Bid from human, mouse, rat and rabbit.

Immunogen

Recombinant full length GST-tagged mouse Bid protein

Application

Detect Bid using this Anti-Bid Antibody validated for use in WB, IP, IH.
Research Category
Apoptosis & Cancer
Research Sub Category
BCL2 & Inhibition
Western blot: Recommended antibody dilution 1:3,000 to 1:6,000. Recognizes a band migrating at approximately 22 kDa corresponding to Bid.

Immunoprecipitation: Recommended antibody dilution 1:200

Immunohistochemistry: Recommended antibody dilution 1:1500

Optimal working dilutions must be determined by end user.

Linkage

Replaces: 04-438

Physical form

Whole serum without preservatives

Storage and Stability

Store at -20°C for up to 12 months.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Weihao Chen et al.
Medical science monitor : international medical journal of experimental and clinical research, 27, e930552-e930552 (2021-04-30)
BACKGROUND Hypertension-related microRNA(miR)-1283 and its target gene, activating transcription factor-4 (ATF4), can regulate vascular endothelial dysfunction. This study aimed to explore whether miR-1283 prevents hypertension through targeting ATF4. MATERIAL AND METHODS Transcriptome sequencing was performed after overexpression or inhibition of

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