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Key Documents

8.55009

Sigma-Aldrich

NovaSyn®TGR resin

Novabiochem®

Synonym(s):

NovaSyn TGR Solid Support Resin

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About This Item

UNSPSC Code:
12352209
NACRES:
NA.22

Quality Level

200

product line

NovaSyn® TG
Novabiochem®

form

beads

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

manufacturer/tradename

Novabiochem®

application(s)

peptide synthesis

functional group

amine

storage temp.

2-8°C

Related Categories

General description

An excellent acid labile support for Fmoc continuous flow and batch synthesis of peptide amides. This resin is prepared from 90 μm NovaSyn TG amino resin by derivatization with the modified Rink linker. It is supplied without Fmoc protection of the linker benzhydrylamine group as this has been found to improve stability. Cleavage is effected with 95% TFA.

Associated Protocols and Technical Articles
Protocols for Loading of Peptide Synthesis Resins

Application

  • An overview of chemical synthesis of antiviral peptides: This study discusses the use of NovaSyn®TGR resin, among others, for peptide synthesis using the Fmoc strategy, particularly highlighting its application in synthesizing antiviral peptides. (Maharani & Muhajir, 2021).

Linkage

Replaces: 01-64-0060

Analysis Note

Color (visual): pale yellow to yellow to beige
Appearance of substance (visual): beads
Loading (determined from the substitution of the Fmoc-Leu loaded resin): 0.20 - 0.30 mmol/g
Swelling Volume (in DMF): lot specific result
The base resin is a PEG-PS copolymer (90 µm) functionalised with the modified Rink linker.

Legal Information

NOVASYN is a registered trademark of Merck KGaA, Darmstadt, Germany
Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Articles

Linkers for Fmoc SPPS

Novabiochem® has one of the most extensive ranges of linkers and derivatized resins for Fmoc solid phase peptide synthesis. These resins have varied properties with special protocols for loading and cleaving.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

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