344095-M

Fluvastatin, Sodium Salt

A synthetic HMG-CoA reductase inhibitor (IC₅₀ = 40-100 nM for human liver microsomes) that acts as an anti-hypercholesterolemic agent.

• Synonym(s): Fluvastatin, Sodium Salt, (±)-(3Rʹ,5Sʹ,6E)-7-[3-(4-Fluorophenyl)-1-isopropylindol-2-yl]-3,5-dihydroxy-6-heptenoate, sodium
• Empirical Formula (Hill Notation): C₂₄H₂₅FNNaO₄
• CAS Number: 93957-55-2
• Molecular Weight: 433.45
• MDL number: MFCD08063391
• UNSPSC Code: 12352200

Properties

• Quality Level: 100
• description: Merck USA index - 14, 4218
• Assay: ≥98% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: light yellow
• solubility: water: 30 mg/mL; DMSO: soluble; methanol: soluble
• storage temp.: −20°C
• SMILES string: [Na+].Fc1ccc(cc1)c2c3c([n](c2\C=C\[C@H](O)C[C@H](O)CC(=O)[O-])C(C)C)cccc3
• InChI: 1S/C24H26FNO4.Na/c1-15(2)26-21-6-4-3-5-20(21)24(16-7-9-17(25)10-8-16)22(26)12-11-18(27)13-19(28)14-23(29)30;/h3-12,15,18-19,27-28H,13-14H2,1-2H3,(H,29,30);/q;+1/p-1/b12-11+;/t18-,19-;/m0./s1
• InChI key: ZGGHKIMDNBDHJB-RPQBTBOMSA-M

Description

General description

A synthetic HMG-CoA reductase inhibitor (IC₅₀ = 40-100 nM for human liver microsomes) that acts as an anti-hypercholesterolemic agent. Decreases the basal MMP-1 levels in culture media of endothelial cells in a time- and dose-dependent manner. Inhibits the formation of TBA-reactive substances in Fe(II)-supported peroxidation of liposomes (IC₅₀ = 12 µM). Also available as a 10 mM solution in H₂O(Cat. No. 344096).

Biochem/physiol Actions

Primary Target
HMG-CoA reductase

Target IC₅₀: 40-100 nM against HMG-CoA reductase in human liver microsomes

Warning

Toxicity: Carcinogenic / Teratogenic (D)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Yamamoto, A., et al. 2001. J. Pharm. Pharmacol.53, 227.
Dansette, P.M., et al. 2000. Exp. Toxicol. Pathol.52, 145.
Ikeda, U., et al. 2000. Hypertension36, 325.
Levy, R.I., et al. 1993. Circulation87 (4 Suppl.), III45.
Tse, F.L.S. et al. 1992. J. Clin. Pharmacol.32, 630.
Yuan, J., et al. 1991. Atherosclerosis87, 147.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable