171601

Amyloid Precursor Protein β-Secretase Inhibitor

The Amyloid Precursor Protein β-Secretase Inhibitor controls the biological activity of Amyloid Precursor Protein β-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.

• Synonym(s): Amyloid Precursor Protein β-Secretase Inhibitor, KTEETSEVN(stat)VAEF
• Empirical Formula (Hill Notation): C₇₃H₁₁₈N₁₆O₂₇
• Molecular Weight: 1651.81
• UNSPSC Code: 12352202
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: lyophilized
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; desiccated (hygroscopic)
• solubility: aqueous buffer, pH 7.5: 1 mg/mL
• shipped in: ambient
• storage temp.: −20°C

Description

General description

A potent inhibitor of the amyloid precursor protein (APP) β-secretase (IC₅₀ = 30 nM).

Biochem/physiol Actions

Cell permeable: no

Primary Target
APP

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 30 nM against amyloid precursor protein (APP) β-secretase

Warning

Toxicity: Standard Handling (A)

Sequence

H-Lys-Thr-Glu-Glu-Ile-Ser-Glu-Val-Asn-Stat-Val-Ala-Glu-Phe-OH [Stat = (3S,4S)-Statine]

Physical form

Supplied as a trifluoroacetate salt.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Sinha, S., et al. 1999. Nature 402, 537.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable