05-23-0600

Substance P

Neuropeptide found in high concentrations in the gut.

• Synonym(s): Substance P, RPKPQQFFGLM
• Empirical Formula (Hill Notation): C₆₃H₉₈N₁₈O₁₃S
• CAS Number: 33507-63-0
• Molecular Weight: 1347.63
• UNSPSC Code: 12352202

Properties

• Quality Level: 100
• Assay: ≥96% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; desiccated (hygroscopic)
• color: white
• solubility: 5% acetic acid: 1 mg/mL
• shipped in: ambient
• storage temp.: −20°C
• InChI: 1S/C63H98N18O13S/c1-37(2)33-45(57(89)74-41(53(68)85)27-32-95-3)73-52(84)36-72-54(86)46(34-38-15-6-4-7-16-38)78-58(90)47(35-39-17-8-5-9-18-39)79-56(88)42(23-25-50(66)82)75-55(87)43(24-26-51(67)83)76-59(91)49-22-14-31-81(49)62(94)44(20-10-11-28-64)77-60(92)48-21-13-30-80(48)61(93)40(65)19-12-29-71-63(69)70/h4-9,15-18,37,40-49H,10-14,19-36,64-65H2,1-3H3,(H2,66,82)(H2,67,83)(H2,68,85)(H,72,86)(H,73,84)(H,74,89)(H,75,87)(H,76,91)(H,77,92)(H,78,90)(H,79,88)(H4,69,70,71)/t40-,41-,42-,43-,44-,45-,46-,47-,48-,49-/m0/s1
• InChI key: ADNPLDHMAVUMIW-CUZNLEPHSA-N

Description

General description

Neuropeptide found in high concentrations in the gut. When released from afferent nerves, causes a neurogenic inflammatory response, including mast cell degranulation. Induces Ca²⁺ mobilization. Reported to activate G_oα, G_q/11α, and G_sα subunits in CHO cells via activation of substance P receptors. Also reported to induce superoxide production in neutrophils.

Biochem/physiol Actions

Cell permeable: no

Primary Target
Substance P receptors

Product does not compete with ATP.

Reversible: no

Packaging

Yes

Warning

Toxicity: Standard Handling (A)

Sequence

H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH₂

Physical form

Supplied as a trifluoroacetate salt.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Roush, E.D., and Kwatra, M.M. 1998. FEBS Lett. 428, 291.
Chiwakata, C.B., et al. 1996. Infect. Immun. 64, 5106.
Tanabe, T., et al. 1996. Eur. J. Pharmacol. 299, 187.
Heath, M.J., et al. 1994. J. Neurophysiol. 72, 1192.
Zhu, J., et al. 1994. Eur. J. Pharmacol. 268, 279.
Garland, A.M., et al. 1993. Soc. Neurosci. 19, Abstract 104.6.
Wei, J.Y., et al. 1993. Soc. Neurosci. 19, Abstract 136.14.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable