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F-003

Supelco

Flurazepam solution

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

Empirical Formula (Hill Notation):
C21H23ClFN3O
CAS Number:
17617-23-1
Molecular Weight:
387.88
EC Number:
200-659-6
MDL number:
MFCD00057324
UNSPSC Code:
41116107
PubChem Substance ID:
329799619
NACRES:
NA.24

grade

certified reference material

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

drug control

Narcotic Licence Schedule B (Switzerland); psicótropo (Spain); Decreto Lei 15/93: Tabela IV (Portugal)

concentration

1.0 mg/mL in methanol

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

clinical testing

format

single component solution

storage temp.

2-8°C

SMILES string

O=C1CN=C(C2=CC=CC=C2F)C3=CC(Cl)=CC=C3N1CCN(CC)CC

InChI

1S/C21H23ClFN3O.2ClH/c1-3-25(4-2)11-12-26-19-10-9-15(22)13-17(19)21(24-14-20(26)27)16-7-5-6-8-18(16)23;;/h5-10,13H,3-4,11-12,14H2,1-2H3;2*1H

InChI key

ZIIJJOPLRSCQNX-UHFFFAOYSA-N

General description

Flurazepam is a benzodiazepine, sold under the trade names Dalmane and Salmadorm for treament of mild to moderate insomnia. This analytical reference standard is suitable for many LC/MS or GC/MS applications from urine drug testing and clinical toxicology to forensic toxicology analysis.

Application


  • Flurazepam in Sleep Research: Flurazepam, a benzodiazepine receptor agonist, is used in sleep epidemiology to explore its effects on sleep patterns and quality. This sedative-hypnotic is evaluated for its potential to improve sleep among various populations, contributing valuable insights into sleep medicine (Fernandez-Mendoza et al., 2024).

  • Pharmacology and GABA Receptors: Studies involving Flurazepam help elucidate its mechanism as a GABAergic compound, particularly in the context of its interaction with GABA(A) receptors. This research is foundational in neuropharmacology, providing deeper understanding of how benzodiazepines modulate neuronal activity and contribute to their therapeutic and side effects (Sun et al., 2023).

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

related product

Product No.
Description
Pricing

D-915

Desalkylflurazepam solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

D-924

Desalkylflurazepam-d4 solution, 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

F-901

2-Hydroxyethylflurazepam solution, 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

F-902

2-Hydroxyethylflurazepam solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

H-919

2-Hydroxyethylflurazepam-d4 solution, 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

H-923

2-Hydroxyethylflurazepam-d4 solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Target Organs

Eyes,Central nervous system

Storage Class Code

3 - Flammable liquids

WGK

WGK 2

Flash Point(F)

49.5 °F - closed cup

Flash Point(C)

9.7 °C - closed cup

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Feng-Zhi Bian et al.
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics, 12(1), 56-61 (2010-02-02)
Benzodiazepines (BDZ) have many effects on various kinds of epilepsies, but long-term treatment with BDZ often leads to drug tolerance. This study aimed to seek drugs which can reverse the tolerance of flurazepam (FZP), and to explore the role of
M Dao Duong Thi et al.
The Journal of pharmacy and pharmacology, 61(3), 399-406 (2009-02-19)
To measure the metabolism and toxicity of 7-chloro-4-(cyclohexylmethyl)-1-methyl-3,4-dihydro-1H-1,4-benzodiazepine-2,5-dione (BNZ-1) and 4-cyclohexylmethyl-1-methyl-3,4-dihydro-1H-1,4-benzodiazepine-2,5-dione (BNZ-2), two new benzodiazepine analogues found to be effective against Leishmania amastigotes in vitro. The metabolism of BNZ-1 and -2 was investigated in isolated rat hepatocytes and rat liver
Julia Boyle et al.
Human psychopharmacology, 24(1), 61-71 (2008-11-06)
To evaluate the next-day residual effects of the novel hypnotic, gaboxadol, following bedtime dosing in healthy elderly subjects. Healthy women (N = 15) and men (N = 10) aged 65-79 years received a single bedtime (22:00 h) dose of gaboxadol
K Xiang et al.
Neuroscience, 157(1), 153-163 (2008-09-23)
One week oral flurazepam (FZP) administration in rats results in reduced GABA(A) receptor-mediated synaptic transmission in CA1 pyramidal neurons associated with benzodiazepine tolerance in vivo and in vitro. Since voltage-gated calcium channel (VGCC) current density is enhanced twofold during chronic
Kenichi Tsunoda et al.
International journal of geriatric psychiatry, 25(12), 1259-1265 (2010-01-08)
Benzodiazepines (BZDs) have been reported to cause negative impacts on body stability and cognitive functions, which in turn could result in lethal incidents, including falls, especially in the elderly. This fact notwithstanding, no systematic trial has evaluated the feasibility and
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