890890P

18:1 TAP (DOTAP)

Avanti Polar Lipids

• Synonym(s): 1,2-dioleoyl-3-trimethylammonium-propane (chloride salt), DOTAP
• Empirical Formula (Hill Notation): C₄₂H₈₀NO₄Cl
• CAS Number: 132172-61-3
• Molecular Weight: 698.54
• UNSPSC Code: 12352211
• NACRES: NA.25

Properties

• form: powder
• packaging: pkg of 1 × 1 g ((890890P-1G)); pkg of 2 × 100 mg ((890890P-200MG)); pkg of 5 × 100 mg ((890890P-100MG)); pkg of 1 × 25 mg ((890890P-25MG))
• manufacturer/tradename: Avanti Polar Lipids
• application(s): advanced drug delivery
• lipid type: transfection; cationic lipids
• shipped in: dry ice
• storage temp.: −20°C
• SMILES string: [H]C(C[N+](C)(C)C)(OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O.[Cl-]
• InChI: 1S/C42H80NO4.ClH/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-34-36-41(44)46-39-40(38-43(3,4)5)47-42(45)37-35-33-31-29-27-25-23-21-19-17-15-13-11-9-7-2;/h20-23,40H,6-19,24-39H2,1-5H3;1H/q+1;/p-1/b22-20-,23-21-;
• InChI key: KSXTUUUQYQYKCR-LQDDAWAPSA-M

Description

Application

18:1 TAP (DOTAP) has been used in chloroform solutions to form dry film in the preparation of cationic liposomes. It has also been used in standard stock solution used for the preparation of cationic liposomes.

Biochem/physiol Actions

DOTAP (1,2-dioleoyl-3-trimethylammonium-propane) is a cationic lipid structure, used for in vitro and in vivo nucleic acid and protein delivery. The lipid composition and cell type affects the transfection potential of DOTAP. DOTAP mediates gene knockdown technique in hematopoietic stem cells (HSCs).

Packaging

5 mL Clear Glass Sealed Ampule (890890P-200mg)

5 mL Clear Glass Sealed Ampule (890890P-25mg)

5 mL Clear Glass Sealed Ampule (890890P-500mg)

60 mL Amber Wide Mouth Screw Cap Glass Bottle (890890P-1g)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable