721034

5-Chloro-3-pyridineboronic acid

≥95%

• Synonym(s): (3-Chloro-5-pyridyl)boronic acid, (3-Chloropyridin-5-yl)boronic acid, (5-Chloropyridin-3-yl)boronic acid, 3-Chloropyridine-5-boronic acid, 5-Chloropyridine-3-boronic acid
• Empirical Formula (Hill Notation): C₅H₅BClNO₂
• CAS Number: 872041-85-5
• Molecular Weight: 157.36
• MDL number: MFCD06798243
• UNSPSC Code: 12352103
• PubChem Substance ID: 329763814
• NACRES: NA.22

Properties

• Quality Level: 100
• Assay: ≥95%
• form: solid
• mp: 255-260 °C
• storage temp.: 2-8°C
• SMILES string: OB(O)c1cncc(Cl)c1
• InChI: 1S/C5H5BClNO2/c7-5-1-4(6(9)10)2-8-3-5/h1-3,9-10H
• InChI key: NJXYBTMCTZAUEE-UHFFFAOYSA-N

Description

Application

5-Chloro-3-pyridineboronic acid can be used as an intermediate:

• In the preparation of positron emission tomography (PET) radioligand [¹¹C]MK-1064, which is applicable in the orexin-2 receptor imaging.
• In the synthesis of orexin 2 receptor antagonist (2-SORA) MK-1064.
• In the preparation of pyridyl-cycloalkyl derived microsomal prostaglandin E synthase-1 inhibitors.
• In the synthesis of ATAD2 bromodomain inhibitors.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H315 - H319 - H335
• Precautionary Statements: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable