132195

Trimethyl phosphate

97%

• Synonym(s): TMP, TMPA, TMPO
• Linear Formula: (CH₃O)₃PO
• CAS Number: 512-56-1
• Molecular Weight: 140.07
• Beilstein: 1071731
• EC Number: 208-144-8
• MDL number: MFCD00008348
• UNSPSC Code: 12352100
• PubChem Substance ID: 24847552
• NACRES: NA.22

Properties

• Assay: 97%
• form: liquid
• refractive index: n20/D 1.395 (lit.)
• bp: 197 °C (lit.)
• mp: −46 °C (lit.)
• density: 1.197 g/mL at 25 °C (lit.)
• SMILES string: COP(=O)(OC)OC
• InChI: 1S/C3H9O4P/c1-5-8(4,6-2)7-3/h1-3H3
• InChI key: WVLBCYQITXONBZ-UHFFFAOYSA-N

Description

General description

Trimethyl phosphate is an excellent dipolar aprotic solvent that is used as a methylating agent and acid scavenger in many organic transformations.

Application

Trimethyl phosphate can be used as a methylating agent for the:

• Solvent-free o-methylation of phenolic compounds to synthesize methyl aryl ethers.
• S-methylation of aryl/alkyl thiols to synthesize S-methylated product in the presence of Ca(OH)₂ as a base.

Safety Information

• Pictograms: GHS08,GHS07
• Signal Word: Danger
• Hazard Statements: H302,H315,H319,H340,H351
• Precautionary Statements: P202 - P264 - P301 + P312 - P302 + P352 - P305 + P351 + P338 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Muta. 1B - Skin Irrit. 2
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 1
• Flash Point(F): 302.0 °F - closed cup
• Flash Point(C): 150 °C - closed cup
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves