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Amination of Aryl Halides and Esters Using Intensified Continuous Flow Processing.

Amination of Aryl Halides and Esters Using Intensified Continuous Flow Processing.

Molecules (Basel, Switzerland) (2015-10-02)

Thomas M Kohl, Christian H Hornung, John Tsanaktsidis

ZUSAMMENFASSUNG

Significant process intensification of the amination reactions of aryl halides and esters has been demonstrated using continuous flow processing. Using this technology traditionally difficult amination reactions have been performed safely at elevated temperatures. These reactions were successfully conducted on laboratory scale coil reactor modules with 1 mm internal diameter (ID) and on a preparatory scale tubular reactor with 6 mm ID containing static mixers.

MATERIALIEN

Produktnummer

Marke

Produktbeschreibung

Sigma-Aldrich

Dimethylsulfoxid, Hybri-Max^™, sterile-filtered, BioReagent, suitable for hybridoma, ≥99.7%

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Dimethylsulfoxid, ACS reagent, ≥99.9%

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Dimethylsulfoxid, for molecular biology

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2-Propanol, ACS reagent, ≥99.5%

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Methanol, ACS reagent, ≥99.8%

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Dichlormethan, contains 40-150 ppm amylene as stabilizer, ACS reagent, ≥99.5%

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Dimethylsulfoxid, sterile-filtered, BioPerformance Certified, meets EP, USP testing specifications, suitable for hybridoma

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Dimethylsulfoxid, ReagentPlus^®, ≥99.5%

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Dimethylsulfoxid, ≥99.5% (GC), suitable for plant cell culture

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Ammoniak -Lösung, 7 N in methanol

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Dimethylsulfoxid, puriss. p.a., ACS reagent, ≥99.9% (GC)

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Isopropylalkohol, meets USP testing specifications

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2-Propanol, puriss. p.a., ACS reagent, reag. ISO, reag. Ph. Eur., ≥99.8% (GC)

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Methanol, puriss. p.a., ACS reagent, reag. ISO, reag. Ph. Eur., ≥99.8% (GC)

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2-Propanol, Laboratory Reagent, ≥99.5%

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Dichlormethan, ACS reagent, ≥99.5%, contains 40-150 ppm amylene as stabilizer

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Methanol, Laboratory Reagent, ≥99.6%

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Dichlormethan, puriss. p.a., ACS reagent, reag. ISO, ≥99.9% (GC)

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Isopropylalkohol, ≥99.7%, FCC, FG

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Methanol, Absolute - Acetone free

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Methanol, ACS spectrophotometric grade, ≥99.9%

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Dimethylsulfoxid, BioUltra, for molecular biology, ≥99.5% (GC)

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Methanol, BioReagent, ≥99.93%

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Ammoniak -Lösung, 0.4 M in dioxane

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2-Propanol, puriss. p.a., ACS reagent, ≥99.8% (GC)

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2-Propanol, BioUltra, for molecular biology, ≥99.5% (GC)

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Methylamin -Lösung, 2.0 M in THF

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Dichlormethan, anhydrous, ≥99.8%, contains 40-150 ppm amylene as stabilizer