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USP

Mercaptopurin

United States Pharmacopeia (USP) Reference Standard

Synonym(e):

6-Mercaptopurin Monohydrat, 6-Purinthiol, 6-Thiohypoxanthin

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About This Item

Empirische Formel (Hill-System):
C5H4N4S · H2O
CAS-Nummer:
6112-76-1
Molekulargewicht:
170.19
Beilstein:
4012091
MDL-Nummer:
MFCD03854445
UNSPSC-Code:
41116107
PubChem Substanz-ID:
329750368
NACRES:
NA.24

Qualität

pharmaceutical primary standard

API-Familie

mercaptopurine

Hersteller/Markenname

USP

mp (Schmelzpunkt)

>300 °C (lit.)

Anwendung(en)

pharmaceutical (small molecule)

Format

neat

SMILES String

O.Sc1ncnc2[nH]cnc12

InChI

1S/C5H4N4S.H2O/c10-5-3-4(7-1-6-3)8-2-9-5;/h1-2H,(H2,6,7,8,9,10);1H2

InChIKey

WFFQYWAAEWLHJC-UHFFFAOYSA-N

Angaben zum Gen

human ... PPAT(5471)

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Allgemeine Beschreibung

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Anwendung

Mercaptopurine USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Azathioprine
  • Azathioprine Sodium for Injection
  • Azathioprine Tablets
  • Mercaptopurine
  • Mercaptopurine Tablets

Hinweis zur Analyse

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Sonstige Hinweise

Sales restrictions may apply.

Piktogramme

Skull and crossbonesHealth hazard
GHS06,GHS08

Signalwort

Danger

Gefahreneinstufungen

Acute Tox. 3 Oral - Muta. 2 - Repr. 2

Lagerklassenschlüssel

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Balraj Singh et al.
PloS one, 9(10), e109487-e109487 (2014-10-04)
A major obstacle in developing effective therapies against solid tumors stems from an inability to adequately model the rare subpopulation of panresistant cancer cells that may often drive the disease. We describe a strategy for optimally modeling highly abnormal and
Qing Qin et al.
Journal of molecular and cellular cardiology, 77, 20-28 (2014-10-07)
Endothelin-1 (ET-1) produced by vascular endothelial cells plays essential roles in the regulation of vascular tone and development of cardiovascular diseases. The objective of this study is to identify novel regulators implicated in the regulation of ET-1 expression in vascular
Kanika V Choughule et al.
Drug metabolism and disposition: the biological fate of chemicals, 42(8), 1334-1340 (2014-05-16)
Anticancer agent 6-mercaptopurine (6MP) has been in use since 1953 for the treatment of childhood acute lymphoblastic leukemia (ALL) and inflammatory bowel disease. Despite being available for 60 years, several aspects of 6MP drug metabolism and pharmacokinetics in humans are
S Bunda et al.
Oncogene, 34(6), 789-797 (2014-01-29)
Juvenile myelomonocytic leukaemia (JMML) is an aggressive myeloproliferative neoplasm in children characterized by granulocyte macrophage colony-stimulating factor (GM-CSF) hypersensitivity and resistance to chemotherapy. We recently identified c-Cbl (henceforth referred to as Cbl) as a GM-CSF receptor (GMR) responsive protein that
Leanna Cheung et al.
Biochemical pharmacology, 91(1), 97-108 (2014-06-29)
Multidrug resistance protein 4 (MRP4/ABCC4), a member of the ATP-binding cassette (ABC) transporter superfamily, is an organic anion transporter capable of effluxing a wide range of physiologically important signalling molecules and drugs. MRP4 has been proposed to contribute to numerous
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