CRM03054

Tetramethrin

mixture of stereoisomers, certified reference material, TraceCERT^®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

• Empirische Formel (Hill-System): C₁₉H₂₅NO₄
• CAS-Nummer: 7696-12-0
• Molekulargewicht: 331.41
• Beilstein: 8807938
• MDL-Nummer: MFCD00084635
• UNSPSC-Code: 41116107
• NACRES: NA.24

Eigenschaften

• Qualität: certified reference material; TraceCERT^®
• Qualitätsniveau: 300
• Produktlinie: TraceCERT^®
• Haltbarkeit: limited shelf life, expiry date on the label
• Zusammensetzung: cis-Tetramethrin, <25.0% (minor component)
• Hersteller/Markenname: Manufactured by: Sigma-Aldrich Production GmbH, Switzerland
• Lagertemp.: −20°C
• SMILES String: C\C(C)=C\C1C(C(=O)OCN2C(=O)C3=C(CCCC3)C2=O)C1(C)C
• InChI: 1S/C19H25NO4/c1-11(2)9-14-15(19(14,3)4)18(23)24-10-20-16(21)12-7-5-6-8-13(12)17(20)22/h9,14-15H,5-8,10H2,1-4H3
• InChIKey: CXBMCYHAMVGWJQ-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

This certified reference material (CRM) is produced and certified in accordance with ISO/IEC 17025 and ISO 17034. This CRM is traceable to primary material from an NMI, e.g. NIST or NMIJ. Certified content by quantitative NMR incl. uncertainty and expiry date are given on the certificate. Download your certificate at: http://www.sigma-aldrich.com.

Tetramethrin, a type I pyrethroid, is used worldwide to protect crops and mammals from a variety of pests such as flies, fleas, mosquitoes, headlice, and mites. Tetramethrin is a synthetic pyrethroid insecticide, that binds to voltage-gated sodium channels of insect nerves and prevents its transition from an activated (ion-conducting) to an inactivated (non-conducting) state. This leads to a permanent depolarization of axonal membranes, causing paralysis and death of an insect.


Tetramethrin is not approved for use in the EU.
The maximum residue limits (MRLs) of pyrethroids compounds in fruits and fruit juices have been set at 0.02 to 0.5 mg/kg in China (GB2763-2019), and 0.02 to 0.3 mg/kg in European Union (EU) (Part A of Annex to Reg. 396/2005), respectively.

Anwendung

It is intended to be used as a certified reference material (CRM) for calibration in chromatography and other analytical techniques. Tetramethrin in CRM may also find its use as described below:

• Study of Estrogenic activity of tetramethrin in uterine CaBP-9k gene expression and a uterotrophic assay, and androgenic activity in Hershberger assay
• To synthesize bis-dihydroxyboron fluorescein complexes for developing a ratiometric fluorescence probe used in the direct detection of pyrethroid residues in fruit juices
• Separation of the four isomers of tetramethrin with ecotoxicity test and quantitative analysis in agrochemical formulations using chiral electrokinetic chromatography methodology
• Residual detection of acetanilide, pentylenetetrazole, phenacetin, and tetramethrin in porcine muscle, pasteurized milk, and eggs by liquid chromatography-electrospray ionization tandem mass spectrometry (LC/ESI-MS/MS) method
• To test glucocorticoid-like activity of propylparaben, butylparaben, diethylhexyl phthalate, and tetramethrin mixtures in different combinations at real human exposure levels

Rechtliche Hinweise

TraceCERT is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Piktogramme: GHS06,GHS08,GHS09
• Signalwort: Danger
• H-Sätze: H302,H331,H351,H371,H410
• P-Sätze: P202 - P260 - P273 - P301 + P312 - P304 + P340 + P311 - P308 + P311
• Gefahreneinstufungen: Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 2 - STOT SE 2 Inhalation
• Zielorgane: Nervous system
• Lagerklassenschlüssel: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 2