T5330

Tanshinone I

≥98% (HPLC)

• Synonym(e): Tanshinon A
• Empirische Formel (Hill-System): C₁₈H₁₂O₃
• CAS-Nummer: 568-73-0
• Molekulargewicht: 276.29
• MDL-Nummer: MFCD00210563
• UNSPSC-Code: 12352205
• PubChem Substanz-ID: 329826820
• NACRES: NA.25

Eigenschaften

• Qualitätsniveau: 200
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: red
• Löslichkeit: DMSO: 1 mg/mL
• Anwendung(en): metabolomics; vitamins, nutraceuticals, and natural products
• Lagertemp.: 2-8°C
• SMILES String: Cc1coc2-c3ccc4c(C)cccc4c3C(=O)C(=O)c12
• InChI: 1S/C18H12O3/c1-9-4-3-5-12-11(9)6-7-13-15(12)17(20)16(19)14-10(2)8-21-18(13)14/h3-8H,1-2H3
• InChIKey: AIGAZQPHXLWMOJ-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

Tanshinone I (Tan I) is a phenolic compound primarily isolated from Danshen. It has an abietane diterpene norditerpenoid o-quinones structure. Tan I have poor water solubility.

Anwendung

Tanshinone 1 has been used:

• to test its hematopoiesis effects on human leukemia cell lines and zebrafish xenograft models
• to study its anti-cancer effects on two breast cancer cell lines (MCF7 and MDA-MB-23)
• as a reference standard to quantify the bioactive component S. miltiorrhiza extract (SME) using high-performance liquid chromatography (HPLC)

Biochem./physiol. Wirkung

Phenanthrenchinon ist ein Bestandteil der chinesischen Heilpflanze Danshen (Salvia miltiorrhiza). Moduliert oder verhindert Metastasierung von Brustkrebs durch die Regelung der Adhäsionsmoleküle. Entzündungshemmend.

TanshinoneI is extensively studied for its anticancer properties, it was reported to inhibit cancer cell invasion, metastasis, and migration and is a potent antitumor agent. It also displays antibacterial, neuroprotective, memory-enhancing, and cardioprotective activities.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable