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T0953

Sigma-Aldrich

14-3-3 Tau/Theta histidine-tagged human

recombinant, expressed in E. coli, C-terminal, ≥90% (SDS-PAGE), buffered aqueous glycerol solution

Synonym(e):

14-3-3 tau, 14-3-3 theta, 14-3-3t, 1C5, Bap1, HS1, Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide, YWHAQ

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About This Item

UNSPSC-Code:
12352202

Rekombinant

expressed in E. coli

Qualitätsniveau

200

Assay

≥90% (SDS-PAGE)

Form

buffered aqueous glycerol solution

Mol-Gew.

~30 kDa (14-3-3 proteins)

UniProt-Hinterlegungsnummer

P27348

Versandbedingung

dry ice

Lagertemp.

−20°C

Angaben zum Gen

human ... YWHAQ(10971)

Biochem./physiol. Wirkung

14-3-3 proteins are involved in a multitude of biological processes and play a regulatory role in processes such as apoptotic cell death, mitogenic signal transduction, and cell cycle control. Co-immunoprecipitation experiments demonstrate the interaction of 14-3-3 τ/θ adaptor protein with various proteins (UCP3, PKCζ). 14-3-3 τ/θ is involved in cell cycle arrest and cellular differentiation. 14-3-3 τ/θ plays an active role in mediating Vpr-induced cell cycle arrest in human T cells.

Physikalische Form

Supplied as a 0.2 μm filtered solution in 50 mM Tris-HCl, pH 7.6, 1 mM EDTA, 1 mM DTT, and 20% glycerol (w/v).

Lagerklassenschlüssel

10 - Combustible liquids

WGK

WGK 1

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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Analysenzertifikate (COA)

Lot/Batch Number

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14-3-3 isotypes facilitate coupling of protein kinase Cζ to Raf-1: negative regulation by 14-3-3 phosphorylation.
Van Der Hoeven, P.C., et al.
The Biochemical Journal, 15, 297-306 (2000)
Mathematical biology in Biology Direct.
Andrei Yakovlev
Biology direct, 3, 1-1 (2008-01-18)
B Pierrat et al.
European journal of biochemistry, 267(9), 2680-2687 (2000-04-28)
Uncoupling proteins (UCPs) are members of the superfamily of the mitochondrial anion carrier proteins (MATP). Localized in the inner membrane of the organelle, they are postulated to be regulators of mitochondrial uncoupling. UCP2 and 3 may play an important role
14-3-3 proteins: active cofactors in cellular regulation by serine/threonine phosphorylation.
Guri Tzivion et al.
The Journal of biological chemistry, 277(5), 3061-3064 (2001-11-16)
José M A Moreira et al.
Molecular & cellular proteomics : MCP, 7(7), 1225-1240 (2008-04-02)
The 14-3-3 proteins constitute a family of highly conserved and broadly expressed multifunctional polypeptides that are involved in a variety of important cellular processes that include cell cycle progression, growth, differentiation, and apoptosis. Although the exact cellular function(s) of 14-3-3

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