SRP8010

GPX1 human

recombinant, expressed in E. coli, His tagged, >90% (SDS-PAGE)

• Synonym(e): Cellular glutathione peroxidase, Death receptor 6, GSHPx-1, Glutathione peroxidase 1
• CAS-Nummer: 1451392-36-1
• UNSPSC-Code: 12352200
• NACRES: NA.32

Eigenschaften

• Biologische Quelle: human
• Rekombinant: expressed in E. coli
• Markierung: His tagged
• Assay: >90% (SDS-PAGE)
• Form: lyophilized
• Mol-Gew.: ~25 kDa by SDS-PAGE
• Verpackung: pkg of 10 μg
• Lagerbedingungen: avoid repeated freeze/thaw cycles
• Verunreinigungen: <1 EU/μg endotoxin, tested
• Farbe: white
• UniProt-Hinterlegungsnummer: P07203
• Versandbedingung: wet ice
• Lagertemp.: −20°C
• Angaben zum Gen: human ... GPX1(2876)

Beschreibung

Allgemeine Beschreibung

GPX1 (glutathione peroxidase 1) is a selenoprotein and the gene is mapped to human chromosome 3p21.3. It is present in the cytoplasm and is widely expressed.

Biochem./physiol. Wirkung

GPX1 (glutathione peroxidase 1) is responsible for scavenging free radicals and derivatives. GPXs reduces lipid hydroperoxides to the corresponding alcohols as well as free hydrogen peroxide to water. Mutations in the GPX1 gene are associated with nonalcoholic fatty liver disease (NAFLD) susceptibility. Mutation in GPX1 at C594T is linked with oxidative stress-associated disorders, including prostate cancer and bladder cancer.

Physikalische Form

Lyophilized from 55 mM TRIS-HCl, pH 8.2, containing 150 mM NaCl, 1 mM DTT.

Rekonstituierung

Reconstitute with 100 μL deionized water.

Sonstige Hinweise

Human GPX1 (aa 1-201) is fused at the C-terminus to a His-tag.

Sicherheitshinweise

• Lagerklassenschlüssel: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable