SRP5227

PAD6, GST tagged human

recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

• Synonym(e): PADI6
• UNSPSC-Code: 12352200
• NACRES: NA.32

Eigenschaften

• Rekombinant: expressed in baculovirus infected Sf9 cells
• Assay: ≥70% (SDS-PAGE)
• Form: buffered aqueous glycerol solution
• Mol-Gew.: ~100 kDa
• NCBI-Hinterlegungsnummer: NM_207421
• Versandbedingung: dry ice
• Lagertemp.: −70°C
• Angaben zum Gen: human ... PADI6(353238)

Beschreibung

Allgemeine Beschreibung

Peptidyl arginine deiminase 6 (PAD6) or PADI6 is a member of the peptidylarginine deiminases. It is expressed in oocytes and preimplantation embryos. The gene encoding this protein is localized on human chromosome 1p36.

Biochem./physiol. Wirkung

Peptidyl arginine deiminases (PADs) convert arginine residues to citrulline residues in the presence of calcium ions. The PAD family members are thought to be involved in multiple sclerosis and rheumatoid arthritis pathophysiology, and they play a role in epidermis homeostasis. PAD6 is essential for formation of a novel oocyte-restricted fibrous structure, the cytoplasmic lattices (CPLs). PAD6/CPL superstructure plays a key role in regulating microtubule-mediated organelle positioning and movement.

Physikalische Form

Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

Angaben zur Herstellung

after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles

Hinweis zur Analyse

This protein is not assayed for enzymatic activity.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable