SRP5177
CREB1 (1-280), GST tagged from rat
recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
Synonym(e):
Creb
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Alle Fotos(1)
About This Item
UNSPSC-Code:
12352202
NACRES:
NA.32
Empfohlene Produkte
Biologische Quelle
rat
Rekombinant
expressed in E. coli
Assay
≥70% (SDS-PAGE)
Form
buffered aqueous glycerol solution
Mol-Gew.
~59 kDa
NCBI-Hinterlegungsnummer
Anwendung(en)
cell analysis
Versandbedingung
dry ice
Lagertemp.
−70°C
Angaben zum Gen
rat ... Creb1(81646)
Allgemeine Beschreibung
CREB1 is a member of the cAMP responsive element binding protein family of transcription factors that are critical mediators of gene expression in response to extracellular signals and are essential regulators of adaptive behavior and long-term memory formation. Activation of CREB1 by protein kinase A-mediated phosphorylation has been implicated in the survival of mammalian cells. Mice lacking CREB in the central nervous system during development show extensive apoptosis of postmitotic neurons. CREB binds as homo- and heterodimers to promoters containing CRE and activator protein 1 (AP-1) sites to alter target-gene expression).
Physikalische Form
Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Angaben zur Herstellung
after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles
Lagerklassenschlüssel
10 - Combustible liquids
WGK
WGK 1
Analysenzertifikate (COA)
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In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.
Olga Valverde et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 29(6), 1122-1133 (2004-03-19)
The transcription factor cAMP-responsive element binding protein (CREB) has been shown to regulate different physiological responses including drug addiction and emotional behavior. Molecular changes including adaptive modifications of the transcription factor CREB are produced during drug dependence in many regions
Theo Mantamadiotis et al.
Nature genetics, 31(1), 47-54 (2002-04-23)
Control of cellular survival and proliferation is dependent on extracellular signals and is a prerequisite for ordered tissue development and maintenance. Activation of the cAMP responsive element binding protein (CREB) by phosphorylation has been implicated in the survival of mammalian
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