SRP4121

IGF-I from rat

recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC)

• Synonym(e): IGF-I, IGF1, IGFIA, Somatomedin C
• MDL-Nummer: MFCD00081716
• UNSPSC-Code: 12352202
• NACRES: NA.32

Eigenschaften

• Biologische Quelle: rat
• Rekombinant: expressed in E. coli
• Assay: ≥95% (HPLC); ≥95% (SDS-PAGE)
• Form: lyophilized
• Mol-Gew.: ~7.69 kDa
• Verpackung: pkg of 20 μg
• Lagerbedingungen: avoid repeated freeze/thaw cycles
• Verunreinigungen: endotoxin, tested
• NCBI-Hinterlegungsnummer: P08025
• UniProt-Hinterlegungsnummer: P08025
• Versandbedingung: wet ice
• Lagertemp.: −20°C
• Angaben zum Gen: rat ... Igf1(24482)

Beschreibung

Allgemeine Beschreibung

IGF-I (insulin-like growth factor-I) is a member of a family of polypeptide growth factors. Rat IGF-I is a 7.69kDa protein containing 70 amino acid residues.

IGF-I exists in two isoforms (IGF1A and IGF1B) in mouse due to alternative transcription.

Anwendung

IGF-I (Insulin-like Growth Factor-I) from rat has been used to study the the effect of IGF-I, IL-27 (interleukin-27) and IL-35 on the blood flow in the inflamed joints of rats.

IGF-I from rat has also been used to test its effect on the expression of its receptor in rheumatoid arthritis model.

Biochem./physiol. Wirkung

IGF-I (Insulin-like growth factor-I) is a polypeptide growth factor that stimulates the proliferation of a wide range of cell types including muscle, bone and cartilage tissue. It mainly mediates growth and development. IGF-I is required for fetal growth and development. It is also involved in the growth and repair of heart tissues. IGF-I has been linked to neuroplasticity and hippocampal neurogenesis. It is important in the recovery from ischaemic injury.

IGF-I interacts with interleukins IL-27 and IL-35 and may play a role in chronic joint inflammation.

Physikalische Form

Lyophilized without additives.

Rekonstituierung

Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.

Reconstitute in water to a concentration of 0.1-1.0 mg/mL. This solution can then be diluted into other aqueous buffers.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable