SRP0327

PADI-2 human

recombinant, expressed in baculovirus infected Sf9 cells, ≥60% (SDS-PAGE)

• Synonym(e): Peptidyl arginine deiminase, type II
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Biologische Quelle: human
• Rekombinant: expressed in baculovirus infected Sf9 cells
• Assay: ≥60% (SDS-PAGE)
• Form: aqueous solution
• Mol-Gew.: 77 kDa
• Verpackung: pkg of 10 μg
• NCBI-Hinterlegungsnummer: NM_007365
• UniProt-Hinterlegungsnummer: Q9Y2J8
• Versandbedingung: dry ice
• Lagertemp.: −70°C
• Angaben zum Gen: human ... PADI2(11240)

Beschreibung

Allgemeine Beschreibung

Human PADI2, also known as Peptidyl arginine deiminase, type II, (GenBank Accession No. NM_007365), amino acids 1-665 (end) with C-terminal FLAG-tag, MW= 77kDa, expressed in a Baculovirus infected Sf9 cell expression system. Peptidyl arginine deiminase, protein-2 (PADI2) is mapped to human chromosome 1p36. It is expressed in Sertoli cells at the time of testicular development.

Anwendung

Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. PADI-2 human has been used in in vitro binding assays.

Biochem./physiol. Wirkung

Peptidyl arginine deiminase, protein-2 (PADI2) promotes protein citrullination and represses the multiplication of cells. It helps to transform the amino acid arginine in a protein into amino acid citrulline. PADI2 participates in epigenetic mechanisms. It is linked with rheumatoid arthritis.

Physikalische Form

Formulated in 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 80 ng/uL Flag peptide, 3 mMDTT, and 20% Glycerol.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable