SML3846

Motixafortide trifluoroacetate

≥95% (HPLC)

• Synonym(e): TF 14016 trifluoroacetate, B 4F-benzoyl-TN14003 trifluoroacetate, BKT 140 trifluoroacetate, BKT140 trifluoroacetate, N2-(4-Fluorobenzoyl)-L-arginyl-L-arginyl-3-(2-naphthalenyl)-L-alanyl-L-cysteinyl-L-tyrosyl-N5-(aminocarbonyl)-L-ornithyl-L-lysyl-D-lysyl-L-prolyl-L-tyrosyl-L-arginyl-N5-(aminocarbonyl)-L-ornithyl-L-cysteinyl- L-argininamide cyclic (4→13)-disulfide trifluoroacetate, TF14016 trifluoroacetate
• Empirische Formel (Hill-System): C₉₇H₁₄₄FN₃₃O₁₉S₂ · xC₂HF₃O₂
• Molekulargewicht: 2159.52 (free base basis)
• UNSPSC-Code: 51111800
• UNSPSC-Code: 12352200
• NACRES: NA.21

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥95% (HPLC)
• Form: (Powder or Lyophilized powder or film)
• Lagerbedingungen: desiccated
• Farbe: white to off-white
• Lagertemp.: -10 to -25°C
• SMILES String: O=C(NCCCC1NC(C(CCCNC(N)=N)NC(C(CC2=CC=C(C=C2)O)NC(C3N(CCC3)C(C(CCCCN)NC(C(CCCCN)NC(C(CCCNC(N)=O)NC(C(CC4=CC=C(C=C4)O)NC(C(CSSCC(C(NC(CCCNC(N)=N)C(N)=O)=O)NC1=O)NC(C(CC5=CC6=C(C=CC=C6)C=C5)NC(C(CCCNC(N)=N)NC(C(CCCNC(N)=N)NC(C7=CC=C(C=C7)F)=O)=O)=O)=O)=O)=O

Beschreibung

Biochem./physiol. Wirkung

Motixafortide (BKT140, BL-8040) is an orally available, highly selective inverse agonist of CXCR4 (CXC Chemokine Receptor 4). Motixafortide is a potent stem cell mobiliser and anticancer agent. BKT140 potently inhibits CXCL12 induced migration/invasion of small-cell lung cancer cells.

Vorsicht

Hygroscopic

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable