SML3287

Sulfopin

≥98% (HPLC)

• Synonym(e): 2-Chloro-N-(2,2-dimethylpropyl)-N-(tetrahydro-1,1-dioxido-3-thienyl)-acetamide
• Empirische Formel (Hill-System): C₁₁H₂₀ClNO₃S
• CAS-Nummer: 2451481-08-4
• Molekulargewicht: 281.80
• MDL-Nummer: MFCD32860123
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: DMSO: 2 mg/mL, clear
• Lagertemp.: 2-8°C
• SMILES String: [S]1(=O)(=O)CC(CC1)N(CC(C)(C)C)C(=O)CCl
• InChI: 1S/C11H20ClNO3S/c1-11(2,3)8-13(10(14)6-12)9-4-5-17(15,16)7-9/h9H,4-8H2,1-3H3
• InChIKey: NMHVAHHYKGXBMY-UHFFFAOYSA-N

Beschreibung

Biochem./physiol. Wirkung

Sulfopin is an in vivo active, highly potent, and selective covalent inhibitor of the peptidyl-prolyl isomerase NIMA-interacting-1 (Pin1) that binds to active site Cys113. Sulfopin induces downregulation of c-Myc target genes, inhibits tumor progression. It extends survival in murine and zebrafish models of MYCN-driven neuroblastoma, and in a murine model of pancreatic cancer.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable