SML3123

NButGT

≥98% (HPLC)

• Synonym(e): (3aR,5R,6S,7R,7aR)-3a,6,7,7a-Tetrahydro-5-(hydroxymethyl)-2-propyl-5H-pyrano[3,2-d]thiazole-6,7-diol
• Empirische Formel (Hill-System): C₁₀H₁₇NO₄S
• CAS-Nummer: 863918-55-2
• Molekulargewicht: 247.31
• UNSPSC-Code: 41106609
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: DMSO: 2 mg/mL, clear
• Lagertemp.: -10 to -25°C
• SMILES String: CCCC1=N[C@@H]2[C@H]([C@@H]([C@H](O[C@@H]2S1)CO)O)O

Beschreibung

Biochem./physiol. Wirkung

NButGT is a potent and selective inhibitor of O-GlcNAcase (OGA), which elevates O-GlcNAc levels but does not cause insulin resistance in 3T3-L1 adipocytes, and in rats and mice. NButGT does not perturbed glucohomeostasis when used for extended time in rats and mice. NButGT attenuates the accumulation of Aβ, neuroinflammation, and memory in in a mouse model of Alzheimer’s disease. NButGT efficiently increased total O-GlcNAc, improves cardiovascular function and reduced animal mortality in rat model of sepsis.

Specific and potent inhibitor of O-GlcNAcase (OGA)

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable