SML3010

Belinostat

≥98% (HPLC)

• Synonym(e): (2E)-N-Hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2-enamide, (2E)-N-Hydroxy-3-[3-[(phenylamino)sulfonyl]phenyl]-2-propenamide, (E)-N-Hydroxy-3-(3-(N-phenylsulfamoyl)phenyl)acrylamide, PX 105684, PX-105684, PX105684, PXD 101, PXD-101, PXD101
• Empirische Formel (Hill-System): C₁₅H₁₄N₂O₄S
• CAS-Nummer: 866323-14-0
• Molekulargewicht: 318.35
• MDL-Nummer: MFCD08064035
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: DMSO: 2 mg/mL, clear
• Lagertemp.: −20°C
• SMILES String: [S](=O)(=O)(Nc2ccccc2)c1cc(ccc1)\C=C\C(=O)NO
• InChI: 1S/C15H14N2O4S/c18-15(16-19)10-9-12-5-4-8-14(11-12)22(20,21)17-13-6-2-1-3-7-13/h1-11,17,19H,(H,16,18)/b10-9+
• InChIKey: NCNRHFGMJRPRSK-MDZDMXLPSA-N

Beschreibung

Biochem./physiol. Wirkung

Belinostat (PX105684; PXD101) is a potent, hydroxamate class pan-selective histone deacetylases (HDACs) inhibitor (IC50: class I HDAC1/2/3/8 = 41/125/30/216 nM, class IIA HDAC4/7/9 = 115/67/128 nM, class IIB HDAC6 = 82 nM) with anti-cancer efficacy in vitro and in vivo.

Potent, hydroxamate class pan-selective histone deacetylases (HDACs) inhibitor with anti-cancer efficacy in vitro and in vivo.

Sicherheitshinweise

• Piktogramme: GHS08
• Signalwort: Danger
• H-Sätze: H340,H361f,H373
• P-Sätze: P201 - P202 - P260 - P280 - P308 + P313 - P405
• Gefahreneinstufungen: Muta. 1B - Repr. 2 - STOT RE 2
• Lagerklassenschlüssel: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable