SML2880

SGC-CLK-1

≥98% (HPLC)

• Synonym(e): N-(3-Methoxy-5-(trifluoromethyl)phenyl)-4-(6-methoxypyrazolo[1,5-b]pyridazin-3-yl)pyrimidin-2-amine
• Empirische Formel (Hill-System): C₁₉H₁₅F₃N₆O₂
• CAS-Nummer: 748142-15-6
• Molekulargewicht: 416.36
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: DMSO: 2 mg/mL, clear (Warmed)
• Lagertemp.: 2-8°C
• SMILES String: FC(F)(F)C1=CC(OC)=CC(NC2=NC=CC(C3=C(C=C4)N(N=C3)N=C4OC)=N2)=C1

Beschreibung

Biochem./physiol. Wirkung

SGC-CLK-1 is a potent and selective CLK1/2/4 inhibitor (IC50 = 13/4/46 nM by enzyme assay; IC50 = 165/70/100 nM by cell-based NanoBRET assay) with good kinome-wide selectivity (by 403-panel KINOMEscan). SGC-CLK-1 inhibits CLK3 at significantly higher concentrations (IC50 = 363 nM by enzyme assay) and causes only partial STK16 inhibition by cell-based NanoBRET assay.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable