SML2630

Intronistat B hydrobromide

≥98% (HPLC)

• Synonym(e): N-(2-(Pyrrolidin-1-yl)ethyl)-2-(3,4,5-trihydroxybenzoyl) benzofuran-5-carboxamide hydrobromide
• Empirische Formel (Hill-System): C₂₂H₂₂N₂O₆ · xHBr
• Molekulargewicht: 410.42 (free base basis)
• UNSPSC-Code: 51111800
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: powder
• Lagerbedingungen: desiccated
• Farbe: white to dark gray
• Löslichkeit: DMSO: 2 mg/mL, clear
• Lagertemp.: 2-8°C

Beschreibung

Biochem./physiol. Wirkung

Inhibitor of the self-splicing group IIB intron found in fungi

Intronistat B is a potent inhibitor of the self-splicing group IIB intron, a mitochondrial RNA tertiary structure necessary for respiration in fungi, yeast and plants, but not found in vertebrates. Intronistat B was found to have antifungal activity comparable to that of amphotericin B in inhibiting growth of the Candida parapsilosis. It did not inhibit spliceosomal processing, group I intron splicing or splicing of group II introns from subclasses other than subclass IIB and was not toxic to human cells.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3