SML2547

KCC-07

≥98% (HPLC)

• Synonym(e): 3-[[4-(2-Pyridinyl)-2-thiazolyl]amino]phenol
• Empirische Formel (Hill-System): C₁₄H₁₁N₃OS
• CAS-Nummer: 315702-75-1
• Molekulargewicht: 269.32
• MDL-Nummer: MFCD01121976
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: DMSO: 2 mg/mL, clear
• Lagertemp.: 2-8°C
• SMILES String: OC1=CC(NC2=NC(C3=NC=CC=C3)=CS2)=CC=C1
• InChIKey: GIGNWEDIMLUWCT-UHFFFAOYSA-N

Beschreibung

Biochem./physiol. Wirkung

KCC-07 is a brain penetrant, potent and selective inhibitor of MBD2 (methyl-CpG-binding domain protein 2) that inhibits binding of MBD2 to methylated DNA and activates brain specific angiogenesis inhibitor 1 (BAI1) inducing anti-proliferative BAI1/p53/p21 signaling. KCC-07 inhibits medulloblastoma cell proliferation, and inhibits tumor growth in mice xenograft models of medulloblastoma.

brain penetrant, potent and selective inhibitor of MBD2 that inducing anti-proliferative BAI1/p53/p21 signaling

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable