SML2408

UNC3866 trifluoroacetate salt

≥98% (HPLC)

• Synonym(e): N-[4-(1,1-Dimethylethyl)benzoyl]-L-phenylalanyl-L-alanyl-L-leucyl-N6,N6-diethyl-L-lysyl-L-Serine methyl ester trifluoroacetate
• Empirische Formel (Hill-System): C₄₃H₆₆N₆O₈
• Molekulargewicht: 795.02
• UNSPSC-Code: 12352200

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: lyophilized powder (white)
• Farbe: white to off-white
• Versandbedingung: wet ice
• Lagertemp.: −20°C

Beschreibung

Biochem./physiol. Wirkung

Antagonist of chromodomains CBX4/7 of Polycomb repressive complex 1

UNC3866 inhibits the CBX chromodomains of the Polycomb repressive complex 1 (PRC1), which is involved in transcriptional repression. UNC3866 selectively targets CBX4 and CBX7 most potently, with Kd values of ∼100 nM. The PRC1 chromodomains facilitate PRC1-mediated transcriptional repression by targeting the complex to Trimethyllysine 27 on histone 3 (H3K27me3). UNC3866 antagonizes the methyllysine (Kme) reading function, and has been shown to inhibit the PC3 prostate cancer cell proliferation associated with CBX7 overexpression.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable