SML2254

J-113397

≥98% (HPLC)

• Synonym(e): 1-[(3R,4R)-1-(Cyclooctylmethyl)-3-(hydroxymethyl)-4-piperidinyl]-3-ethyl-1,3-dihydro-2H-benzimidazol-2-one
• Empirische Formel (Hill-System): C₂₄H₃₇N₃O₂
• CAS-Nummer: 256640-45-6
• Molekulargewicht: 399.57
• MDL-Nummer: MFCD04113003
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: powder
• Optische Aktivität: [α]/D +7 to +10°, c = 1 in isopropanol
• Lagerbedingungen: desiccated
• Farbe: white to beige
• Löslichkeit: DMSO: 2 mg/mL, clear
• Lagertemp.: room temp
• SMILES String: CCN1C2=CC=CC=C2N([C@H]3[C@H](CO)CN(CC4CCCCCCC4)CC3)C1=O
• InChI: 1S/C24H37N3O2/c1-2-26-22-12-8-9-13-23(22)27(24(26)29)21-14-15-25(17-20(21)18-28)16-19-10-6-4-3-5-7-11-19/h8-9,12-13,19-21,28H,2-7,10-11,14-18H2,1H3/t20-,21+/m0/s1
• InChIKey: MBGVUMXBUGIIBQ-LEWJYISDSA-N

Beschreibung

Biochem./physiol. Wirkung

J-113397 is an antagonist of NOP, the nociceptin/orphanin FQ (N/OFQ) receptor. J-113397 exhibited an IC50 value of 2.3 nM in Chinese hamster ovary (CHO) cells expressing ORL1 receptor showed with 600-fold or less affinity for μ-, δ- and κ-opioid receptors.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable