SML1571

S14161

≥98% (HPLC)

• Synonym(e): 8-Ethoxy-2-(4-fluorophenyl)-3-nitro-2H-1-benzopyran, 8-Ethoxy-2-(4-fluorophenyl)-3-nitro-2H-chromene, Pichromene
• Empirische Formel (Hill-System): C₁₇H₁₄FNO₄
• CAS-Nummer: 883046-50-2
• Molekulargewicht: 315.30
• MDL-Nummer: MFCD00112055
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329825969
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Lagerbedingungen: desiccated; protect from light
• Farbe: white to beige
• Lagertemp.: −20°C
• SMILES String: FC(C=C1)=CC=C1C2C([N+]([O-])=O)=CC3=CC=CC(OCC)=C3O2
• InChI: 1S/C17H14FNO4/c1-2-22-15-5-3-4-12-10-14(19(20)21)16(23-17(12)15)11-6-8-13(18)9-7-11/h3-10,16H,2H2,1H3
• InChIKey: BFZXDHIUPNWOMT-UHFFFAOYSA-N

Beschreibung

Biochem./physiol. Wirkung

S14161 inhibits D-cyclin transactivation by inhibition of phosphoinositide 3-kinase (PI3K) activity. S14161 is a pan-class I PI3K inhibitor. S14161 inhibited the activity of all 4 isoforms of the PI3K class I family, and unlike LY294002, had little effect on class IV enzymes mechanistic target of rapamycin (mTOR) and DNA-PKcs (DNA-dependent protein kinase, catalytic subunit), or on AKT-1, -2, or -3 or PDK1. S14161 inhibited the expression of cyclins D1, D2, and D3, leading to the arrest of cells at the G0/G1 phase, and has exhibited anti-myeloma and anti-leukemia activity with no gross toxicity.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H315
• P-Sätze: P264 - P280 - P302 + P352 - P332 + P313 - P362 + P364
• Gefahreneinstufungen: Skin Irrit. 2
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3