SML1552

Tipiracil hydrochloride

≥98% (HPLC)

• Synonym(e): 5-Chloro-6-[(2-imino-1-pyrrolidinyl)methyl]-2,4(1H,3H)-pyrimidinedione hydrochloride, TPI hydrochloride
• Empirische Formel (Hill-System): C₉H₁₁ClN₄O₂ · HCl
• CAS-Nummer: 183204-72-0
• Molekulargewicht: 279.12
• MDL-Nummer: MFCD01571384
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329825960
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Lagerbedingungen: desiccated
• Farbe: white to beige
• Löslichkeit: H₂O: 5 mg/mL, clear (warmed)
• Lagertemp.: 2-8°C
• SMILES String: [H]Cl.ClC1=C(CN2C(CCC2)=N)NC(NC1=O)=O
• InChI: 1S/C9H11ClN4O2.ClH/c10-7-5(12-9(16)13-8(7)15)4-14-3-1-2-6(14)11;/h11H,1-4H2,(H2,12,13,15,16);1H
• InChIKey: KGHYQYACJRXCAT-UHFFFAOYSA-N
• Angaben zum Gen: human ... TYMP(1890)

Beschreibung

Biochem./physiol. Wirkung

Tipiracil is an inhibitor of thymidine phosphorylase. Tipiracil is used in combination with trifluridine as TAS-102 for the treatment of refractory metastatic colorectal cancer. Tipiracil increases the bioavailability of trifluridine by blocking the enzyme that would otherwise protect the tumors by metabolizing trifluridine.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable