SML1368

CLP257

≥98% (HPLC)

• Synonym(e): (5Z)-5-[(4-Fluoro-2-hydroxyphenyl)methylene]-2-(tetrahydro-1-(2H)-pyridazinyl)-4(5H)-thiazolone
• Empirische Formel (Hill-System): C₁₄H₁₄FN₃O₂S
• CAS-Nummer: 1181081-71-9
• Molekulargewicht: 307.34
• MDL-Nummer: MFCD28166488
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329825822
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: , white to yellow to light brown
• Löslichkeit: DMSO: 20 mg/mL, clear
• Lagertemp.: 2-8°C
• SMILES String: O=C1/C(SC(N2CCCCN2)=N1)=C/C3=CC=C(F)C=C3O
• InChI: 1S/C14H14FN3O2S/c15-10-4-3-9(11(19)8-10)7-12-13(20)17-14(21-12)18-6-2-1-5-16-18/h3-4,7-8,16,19H,1-2,5-6H2/b12-7-
• InChIKey: SKCADXVKQRCWTR-GHXNOFRVSA-N

Beschreibung

Anwendung

CLP257 has been used as a K⁺- Cl^- cotransporter 2 (KCC2) enhancer in human neuron culture.

Biochem./physiol. Wirkung

CLP257 is a selective K⁺-Cl⁻ cotransporter KCC2 activator that restored impaired Cl⁻ transport in neurons with reduced KCC2 activity. Apparently, CLP257 modulates plasmalemmal KCC2 protein turnover post-translationally.

CLP257 is a selective K⁺-Cl⁻ cotransporter KCC2 activator.

In streptozotocin treated rats, by activating a K⁺- Cl^- cotransporter 2 (KCC2) in the arginine-vasopressin neuron, CLP257 mediates γ-aminobutyric acid (GABA)ergic excitation. It is however inactive with KCC1, KCC3 and KCC4.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H302
• P-Sätze: P264 - P270 - P301 + P312 - P501
• Gefahreneinstufungen: Acute Tox. 4 Oral
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable