SML1317

XAP044

≥98% (HPLC)

• Synonym(e): 7-Hydroxy-3-(4-iodophenoxy)-4H-chromen-4-one, XAP 044
• Empirische Formel (Hill-System): C₁₅H₉IO₄
• CAS-Nummer: 196928-50-4
• Molekulargewicht: 380.13
• MDL-Nummer: MFCD00525548
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329825781

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Lagerbedingungen: protect from light
• Farbe: white to beige
• Löslichkeit: DMSO: 20 mg/mL, clear
• Lagertemp.: 2-8°C
• SMILES String: O=C1C(OC2=CC=C(I)C=C2)=COC3=C1C=CC(O)=C3
• InChI: 1S/C15H9IO4/c16-9-1-4-11(5-2-9)20-14-8-19-13-7-10(17)3-6-12(13)15(14)18/h1-8,17H
• InChIKey: XXZKJJYWINSUMJ-UHFFFAOYSA-N

Beschreibung

Biochem./physiol. Wirkung

XAP044 is a brain penetrant, potent and selective mGlu7 (metabotropic glutamate receptor subtype 7) antagonist that inhibits lateral amygdala long-term potentiation (LTP) in brain slices from wild type mice. XAP044 binds to a pocket localized in mGlu7′s extracellular Venus flytrap domain (VFTD) close to the binding site of the orthosteric agonist L-glutamate. XAP044 exhibits a wide-spectrum anti-stress, antidepressant- and anxiolytic-like efficacy in rodent behavioral model.

Sonstige Hinweise

Light sensitive. This compound has Iodine and should be kept in the dark.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable