SML1132

Pep2-8 trifluoroacetate salt

≥95% (HPLC), contains 58μL of solution at 10mM in DMSO

• Synonym(e): Ac-TVFTSWEEYLDWV-NH₂ trifluoroacetate salt, Ac-TVFTSWEEYLDWV-amide trifluoroacetate salt, Ac-Thr-Val-Phe-Thr-Ser-Trp-Glu-Glu-Tyr-Leu-Asp-Trp-Val-NH₂ trifluoroacetate salt
• Empirische Formel (Hill-System): C₈₃H₁₁₀N₁₆O₂₄ · xC₂HF₃O₂
• Molekulargewicht: 1715.85 (free base basis)
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Assay: ≥95% (HPLC)
• Form: solution
• Farbe: colorless to pale yellow
• Versandbedingung: wet ice
• Lagertemp.: −20°C

Beschreibung

Amino Acid Sequence

Ac-Thr-Val-Phe-Thr-Ser-Trp-Glu-Glu-Tyr-Leu-Asp-Trp-Val-NH₂ trifluoroacetate salt

Biochem./physiol. Wirkung

Pep2-8 is a potent PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibitor that selectively binds to PCSK9 and interferes with LDL receptor binding to PCSK9. Pep2-8 restores LDL receptor function and LDL uptake of PCSK9-treated HepG2 cells.

Pep2-8, a good mimic of epidermal growth factor precursor homology domain A (EGF-A), serves as a competitive inhibitor of low-density lipoprotein (LDL) receptor binding. It can be used as an anchor peptide in phage-display experiments to bind an extension peptide library to the groove site.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable