SML0603

Lixivaptan

≥96% (HPLC)

• Synonym(e): N-[3-Chloro-4-(5H-pyrrolo[2,1-c][1,4]benzodiazepine-10(11H)-ylcarbonyl)phenyl]-5-fluoro-2-methylbenzamide, VPA 985, WAY-VPA 985
• Empirische Formel (Hill-System): C₂₇H₂₁ClFN₃O₂
• CAS-Nummer: 168079-32-1
• Molekulargewicht: 473.93
• UNSPSC-Code: 51111800
• NACRES: NA.77

Eigenschaften

• Beschreibung: 4% w/w in ethyl acetate
• Assay: ≥96% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: DMSO: 20 mg/mL, clear
• Lagertemp.: room temp
• InChI: 1S/C27H21ClFN3O2/c1-17-8-9-19(29)13-23(17)26(33)30-20-10-11-22(24(28)14-20)27(34)32-16-21-6-4-12-31(21)15-18-5-2-3-7-25(18)32/h2-14H,15-16H2,1H3,(H,30,33)
• InChIKey: PPHTXRNHTVLQED-UHFFFAOYSA-N

Beschreibung

Biochem./physiol. Wirkung

Arginine vasopressin (AVP) plays an important part in circulatory and water homoeostasis and is important in renal hemodynamic alterations, water retention, and cardiac remodeling in congestive heart failure (CHF). Lixivaptan is an AVP V2-receptor selective antagonist that increases water excretion and normalizes serum sodium levels. Lixivaptan has been in clinical trials for hyponatremia associated with heart failure.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable