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SML0531

Sigma-Aldrich

BIO-Acetoxime

≥98% (HPLC)

Synonym(e):

(2′Z,3′E)-6-Bromoindirubin-3′-acetoxime, (3Z)-3-[(3E)-3-[(Acetyloxy)imino]-1,3-dihydro-2H-indol-2-ylidene]-6-bromo-1,3-dihydro-2H-Indol-2-one, 6-Bromoindirubin acetoxime, 6-Bromoindirubin-3′-acetoxime, BIA

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About This Item

Empirische Formel (Hill-System):
C18H12BrN3O3
CAS-Nummer:
667463-85-6
Molekulargewicht:
398.21
MDL-Nummer:
MFCD09037533
UNSPSC-Code:
12352200
PubChem Substanz-ID:
329825535
NACRES:
NA.77

Qualitätsniveau

100

Assay

≥98% (HPLC)

Form

powder

Farbe

, dark red to purple

Löslichkeit

H2O: 2 mg/mL (clear solution, warmed)

Lagertemp.

2-8°C

SMILES String

CC(=O)O\N=C1\C(Nc2ccccc12)=C3\C(=O)Nc4cc(Br)ccc34

InChI

1S/C18H12BrN3O3/c1-9(23)25-22-16-12-4-2-3-5-13(12)20-17(16)15-11-7-6-10(19)8-14(11)21-18(15)24/h2-8,20H,1H3,(H,21,24)/b17-15-,22-16+

InChIKey

MENDIXKFTXYTHJ-HPBPSMLHSA-N

Biochem./physiol. Wirkung

BIO-Acetoxime is a potent and selective GSK-3a/b inhibitor that reduces invasiveness of gliomas and extends animal survival in intracranial glioma models. Also, BIO-Acetoxime induces Wnt signaling and inhibits CD8+ T cell effector differentiation.

Leistungsmerkmale und Vorteile

This compound is featured on the GSK-3 page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Piktogramme

Exclamation markEnvironment
GHS07,GHS09

Signalwort

Warning

H-Sätze

H302,H410

Gefahreneinstufungen

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

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