SML0473

Noladin ether

≥98% (HPLC)

• Synonym(e): 2-Arachidonylglyceryl ether, 2-[(5Z,8Z,11Z,14Z)-5,8,11,14-Eicosatetraen-1-yloxy]-1,3-propanediol; 2-AG ether, HU 310
• Empirische Formel (Hill-System): C₂₃H₄₀O₃
• CAS-Nummer: 222723-55-9
• Molekulargewicht: 364.56
• EG-Nummer: 200-578-6
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: solution
• Arzneimittelkontrolle: regulated under CDSA - not available from Sigma-Aldrich Canada
• Konzentration: 10 mg/mL in ethanol (1% w/v)
• Farbe: colorless to light yellow
• Versandbedingung: dry ice
• Lagertemp.: −70°C
• SMILES String: O(C(CO)CO)CCCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC
• InChI: 1S/C23H40O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-26-23(21-24)22-25/h6-7,9-10,12-13,15-16,23-25H,2-5,8,11,14,17-22H2,1H3/b7-6-,10-9-,13-12-,16-15-
• InChIKey: CUJUUWXZAQHCNC-DOFZRALJSA-N

Beschreibung

Biochem./physiol. Wirkung

Noladin ether (2-Arachidonyl glycerol ether) is a CB1 agonist.

Noladin ether (2-Arachidonyl glycerol ether) is a stable analog of the endogenous cannabanoid 2-Arachidonylglycerol (2-AG) with selectivity for CB1 receptors. Noladin ether is a CB1 agonist. The Ki values for CB1 vs CB2 receptors are 21.2 nM and 3 mM, respectively. Noladin ether induces sedation and has modest antinociceptive activity in vivo, and reduces inter ocular pressure after administration in the eye.

Sicherheitshinweise

• Piktogramme: GHS02,GHS07
• Signalwort: Danger
• H-Sätze: H225,H319
• P-Sätze: P210 - P233 - P240 - P241 - P242 - P305 + P351 + P338
• Gefahreneinstufungen: Eye Irrit. 2 - Flam. Liq. 2
• Lagerklassenschlüssel: 3 - Flammable liquids
• WGK: WGK 2
• Flammpunkt (°F): 57.2 °F - closed cup
• Flammpunkt (°C): 14.0 °C - closed cup