SML0472
4-IPP
≥97% (HPLC)
Synonym(e):
4-Iodo-6-phenylpyrimidine
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Alle Fotos(1)
About This Item
Empirische Formel (Hill-System):
C10H7IN2
CAS-Nummer:
Molekulargewicht:
282.08
MDL-Nummer:
UNSPSC-Code:
12352200
PubChem Substanz-ID:
NACRES:
NA.77
Empfohlene Produkte
Assay
≥97% (HPLC)
Form
powder
Farbe
white to beige
Löslichkeit
DMSO: 10 mg/mL (clear solution, warmed)
Lagertemp.
−20°C
SMILES String
Ic1cc(ncn1)-c2ccccc2
InChI
1S/C10H7IN2/c11-10-6-9(12-7-13-10)8-4-2-1-3-5-8/h1-7H
InChIKey
ZTCJXHNJVLUUMR-UHFFFAOYSA-N
Anwendung
4-IPP has been used as a macrophage migration inhibitory factor (MIF) in conditioned medium (CM) for in vitro migration assay.
Biochem./physiol. Wirkung
4-IPP is a cell permeable, potent macrophage migration inhibitory factor (MIF) antagonist that covalently modifies MIF N-terminal proline.
4-Iodo-6-phenylpyrimidine (4-IPP) has the potential to be a new anti-polyploid therapeutic agent that may be utilized in patients with thyroid cancer to target polyploid tumor cells. It suppresses osteoclastogenesis by blocking the IMF-κB pathway. 4-IPP can be employed as a therapeutic target for macrophage migration inhibitory factor (MIF) to treat pathologic osteolytic bone diseases and postmenopausal bone loss. It can prevent the development and motility of lung adenocarcinoma cells and can stimulate apoptosis and mitotic death of thyroid carcinomas.
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 3
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