SML0174

GPR35 Agonist, Compound 10

≥98% (HPLC)

• Synonym(e): 2-[4-[(2,4-Dioxo-5-thiazolidinylidene)methyl]phenoxy]-acetic acid
• Empirische Formel (Hill-System): C₁₂H₉NO₅S
• CAS-Nummer: 123021-85-2
• Molekulargewicht: 279.27
• MDL-Nummer: MFCD01835940
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329825204
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to tan
• Löslichkeit: DMSO: ≥5 mg/mL at ~60 °C
• Lagertemp.: 2-8°C
• SMILES String: OC(=O)COc1ccc(cc1)\C=C2/SC(=O)NC2=O
• InChI: 1S/C12H9NO5S/c14-10(15)6-18-8-3-1-7(2-4-8)5-9-11(16)13-12(17)19-9/h1-5H,6H2,(H,14,15)(H,13,16,17)/b9-5-
• InChIKey: WXMCOLGPDOYHNK-UITAMQMPSA-N

Beschreibung

Anwendung

GPR35 Agonist, Compound 10, may be used in GPR35-mediated cell signaling studies.

Biochem./physiol. Wirkung

GPR35 agonist Compound 10 is a GPR35 agonist the binds with higher affinity than other known agonists, such as kynurenic acid and zaprinast. Compound 10 was more potent than zaniprast (pEC50 = 5.3 vs 4.18) for recombinantly expressed human GPR35, and unlike zaprinast, is equipotent for human and rat GPR35

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H319
• P-Sätze: P264 - P280 - P305 + P351 + P338 - P337 + P313
• Gefahreneinstufungen: Eye Irrit. 2
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable