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SML0149

Sigma-Aldrich

3-Ethoxy-5,6-dibromosalicylaldehyde

≥95% (HPLC)

Synonym(e):

2,3-Dibromo-5-ethoxy-6-hydroxy-benzaldehyde, 5,6-Dibromo-o-bourbonal

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About This Item

Empirische Formel (Hill-System):
C9H8Br2O3
CAS-Nummer:
20041-64-9
Molekulargewicht:
323.97
MDL-Nummer:
MFCD00297095
UNSPSC-Code:
12352200
PubChem Substanz-ID:
329825197
NACRES:
NA.77

Qualitätsniveau

100

Assay

≥95% (HPLC)

Form

powder

Lagerbedingungen

desiccated

Farbe

yellow

Löslichkeit

DMSO: ≥15 mg/mL

Lagertemp.

2-8°C

SMILES String

CCOc1cc(Br)c(Br)c(C=O)c1O

InChI

1S/C9H8Br2O3/c1-2-14-7-3-6(10)8(11)5(4-12)9(7)13/h3-4,13H,2H2,1H3

InChIKey

MZAISYPWQNBWED-UHFFFAOYSA-N

Anwendung

3-Ethoxy-5,6-dibromosalicylaldehyde was used to study modulation of autophagy, JNK activation and NF-κB-mediated inflammation.

Biochem./physiol. Wirkung

3-Ethoxy-5,6-dibromosalicylaldehyde is a non-competitive inhibitor of Inositol-requiring enzyme 1 (IRE1). It inhibits XBP-1 splicing induced pharmacologically in human cells. 3-Ethoxy-5,6-dibromosalicylaldehyde potently inhibits the endoribonuclease of IRE1 but does not inhibit RNases A, T1, or L.
3-Ethoxy-5,6-dibromosalicylaldehyde is a non-competitive inhibitor of Inositol-requiring enzyme 1 (IRE1); potent inhibitor of endoribonuclease of IRE1

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

H-Sätze

H302,H317

Gefahreneinstufungen

Acute Tox. 4 Oral - Skin Sens. 1

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

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Analysenzertifikate (COA)

Lot/Batch Number
111M4733V

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